| pubmed-article:20371475 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20371475 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:20371475 | lifeskim:mentions | umls-concept:C0376358 | lld:lifeskim |
| pubmed-article:20371475 | lifeskim:mentions | umls-concept:C0011923 | lld:lifeskim |
| pubmed-article:20371475 | lifeskim:mentions | umls-concept:C1328813 | lld:lifeskim |
| pubmed-article:20371475 | lifeskim:mentions | umls-concept:C1516193 | lld:lifeskim |
| pubmed-article:20371475 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:20371475 | pubmed:dateCreated | 2010-4-7 | lld:pubmed |
| pubmed-article:20371475 | pubmed:abstractText | As current radiological approaches cannot accurately localize prostate cancer in vivo, biopsies are conducted at random within prostates for patients at risk for prostate cancer, leading to high false-negative rates. Metabolomic imaging can map cancer-specific biomolecular profile values onto anatomical structures to direct biopsy. In this preliminary study, we evaluated five whole prostates removed during prostatectomy from biopsy-proven cancer patients on a 7-tesla human whole-body magnetic resonance scanner. Localized, multi-cross-sectional, multivoxel magnetic resonance spectra were used to construct a malignancy index based on prostate cancer metabolomic profiles obtained from previous intact tissue analyses with a 14-tesla spectrometer. This calculated malignancy index is linearly correlated with lesion size and demonstrates a 93 to 97% overall accuracy for detecting the presence of prostate cancer lesions, suggesting the potential clinical utility of this approach. | lld:pubmed |
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| pubmed-article:20371475 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20371475 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20371475 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20371475 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20371475 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:20371475 | pubmed:issn | 1946-6242 | lld:pubmed |
| pubmed-article:20371475 | pubmed:author | pubmed-author:JenkinsBruce... | lld:pubmed |
| pubmed-article:20371475 | pubmed:author | pubmed-author:WuChin-LeeCL | lld:pubmed |
| pubmed-article:20371475 | pubmed:author | pubmed-author:McDougalW... | lld:pubmed |
| pubmed-article:20371475 | pubmed:author | pubmed-author:ChengLeo LLL | lld:pubmed |
| pubmed-article:20371475 | pubmed:author | pubmed-author:RataiEva MEM | lld:pubmed |
| pubmed-article:20371475 | pubmed:author | pubmed-author:ShengJinhuaJ | lld:pubmed |
| pubmed-article:20371475 | pubmed:author | pubmed-author:YingLeslieL | lld:pubmed |
| pubmed-article:20371475 | pubmed:author | pubmed-author:JordanKate... | lld:pubmed |
| pubmed-article:20371475 | pubmed:author | pubmed-author:AdkinsChriste... | lld:pubmed |
| pubmed-article:20371475 | pubmed:author | pubmed-author:DefeoElita... | lld:pubmed |
| pubmed-article:20371475 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20371475 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:20371475 | pubmed:volume | 2 | lld:pubmed |
| pubmed-article:20371475 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20371475 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20371475 | pubmed:pagination | 16ra8 | lld:pubmed |
| pubmed-article:20371475 | pubmed:dateRevised | 2010-9-28 | lld:pubmed |
| pubmed-article:20371475 | pubmed:meshHeading | pubmed-meshheading:20371475... | lld:pubmed |
| pubmed-article:20371475 | pubmed:meshHeading | pubmed-meshheading:20371475... | lld:pubmed |
| pubmed-article:20371475 | pubmed:meshHeading | pubmed-meshheading:20371475... | lld:pubmed |
| pubmed-article:20371475 | pubmed:meshHeading | pubmed-meshheading:20371475... | lld:pubmed |
| pubmed-article:20371475 | pubmed:meshHeading | pubmed-meshheading:20371475... | lld:pubmed |
| pubmed-article:20371475 | pubmed:meshHeading | pubmed-meshheading:20371475... | lld:pubmed |
| pubmed-article:20371475 | pubmed:meshHeading | pubmed-meshheading:20371475... | lld:pubmed |
| pubmed-article:20371475 | pubmed:meshHeading | pubmed-meshheading:20371475... | lld:pubmed |
| pubmed-article:20371475 | pubmed:meshHeading | pubmed-meshheading:20371475... | lld:pubmed |
| pubmed-article:20371475 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20371475 | pubmed:articleTitle | Metabolomic imaging for human prostate cancer detection. | lld:pubmed |
| pubmed-article:20371475 | pubmed:affiliation | Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. | lld:pubmed |
| pubmed-article:20371475 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20371475 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20371475 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
