| pubmed-article:20371182 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20371182 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:20371182 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:20371182 | lifeskim:mentions | umls-concept:C0220825 | lld:lifeskim |
| pubmed-article:20371182 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:20371182 | lifeskim:mentions | umls-concept:C1373120 | lld:lifeskim |
| pubmed-article:20371182 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:20371182 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:20371182 | lifeskim:mentions | umls-concept:C0205460 | lld:lifeskim |
| pubmed-article:20371182 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:20371182 | pubmed:dateCreated | 2010-4-30 | lld:pubmed |
| pubmed-article:20371182 | pubmed:abstractText | A series of novel S-DABO analogues (4a1-5a12) have been synthesized by an efficient method and evaluated as inhibitors of human immunodeficiency virus type-1 (HIV-1). The biological testing results clearly indicated that the substitution of halogen at the C5 position of pyrimidine ring could increase the anti-HIV-1 RT activity. The most active compounds showed activity in the low micromole range with IC(50) values (IC(50) 0.18-3.03 microM) comparable to nevirapine (IC(50) 4.12 microM). The docking showed that a new halogen bond was formed between halogen and carbonyl of TYR188 in the HIV-I RT. | lld:pubmed |
| pubmed-article:20371182 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20371182 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20371182 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20371182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20371182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20371182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20371182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20371182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20371182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20371182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20371182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20371182 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20371182 | pubmed:month | May | lld:pubmed |
| pubmed-article:20371182 | pubmed:issn | 1464-3391 | lld:pubmed |
| pubmed-article:20371182 | pubmed:author | pubmed-author:RaiK CKC | lld:pubmed |
| pubmed-article:20371182 | pubmed:author | pubmed-author:GuoYingY | lld:pubmed |
| pubmed-article:20371182 | pubmed:author | pubmed-author:LiuChangC | lld:pubmed |
| pubmed-article:20371182 | pubmed:author | pubmed-author:CuiYuxinY | lld:pubmed |
| pubmed-article:20371182 | pubmed:author | pubmed-author:WangXiaoweiX | lld:pubmed |
| pubmed-article:20371182 | pubmed:author | pubmed-author:WangRuipingR | lld:pubmed |
| pubmed-article:20371182 | pubmed:author | pubmed-author:LiuJunyiJ | lld:pubmed |
| pubmed-article:20371182 | pubmed:author | pubmed-author:MaLiyingL | lld:pubmed |
| pubmed-article:20371182 | pubmed:author | pubmed-author:HsuS-BSB | lld:pubmed |
| pubmed-article:20371182 | pubmed:author | pubmed-author:ZhangJianfang... | lld:pubmed |
| pubmed-article:20371182 | pubmed:copyrightInfo | (c) 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20371182 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20371182 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:20371182 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:20371182 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20371182 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20371182 | pubmed:pagination | 3231-7 | lld:pubmed |
| pubmed-article:20371182 | pubmed:meshHeading | pubmed-meshheading:20371182... | lld:pubmed |
| pubmed-article:20371182 | pubmed:meshHeading | pubmed-meshheading:20371182... | lld:pubmed |
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| pubmed-article:20371182 | pubmed:meshHeading | pubmed-meshheading:20371182... | lld:pubmed |
| pubmed-article:20371182 | pubmed:meshHeading | pubmed-meshheading:20371182... | lld:pubmed |
| pubmed-article:20371182 | pubmed:meshHeading | pubmed-meshheading:20371182... | lld:pubmed |
| pubmed-article:20371182 | pubmed:meshHeading | pubmed-meshheading:20371182... | lld:pubmed |
| pubmed-article:20371182 | pubmed:meshHeading | pubmed-meshheading:20371182... | lld:pubmed |
| pubmed-article:20371182 | pubmed:meshHeading | pubmed-meshheading:20371182... | lld:pubmed |
| pubmed-article:20371182 | pubmed:meshHeading | pubmed-meshheading:20371182... | lld:pubmed |
| pubmed-article:20371182 | pubmed:meshHeading | pubmed-meshheading:20371182... | lld:pubmed |
| pubmed-article:20371182 | pubmed:meshHeading | pubmed-meshheading:20371182... | lld:pubmed |
| pubmed-article:20371182 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20371182 | pubmed:articleTitle | Synthesis and biological evaluation of novel C5 halogen-functionalized S-DABO as potent HIV-1 non-nucleoside reverse transcriptase inhibitors. | lld:pubmed |
| pubmed-article:20371182 | pubmed:affiliation | State key Laboratory of National and Biomimetic Drug, Peking University, Beijing 100191, PR China. | lld:pubmed |
| pubmed-article:20371182 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20371182 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20371182 | lld:chembl |
