| pubmed-article:20370577 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C0044602 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C0123257 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C0285761 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C1368105 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C1451005 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C1705325 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C0596890 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C0164786 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C0812228 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C1150481 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:20370577 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:20370577 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20370577 | pubmed:dateCreated | 2010-10-5 | lld:pubmed |
| pubmed-article:20370577 | pubmed:abstractText | Insulin-like growth factor binding protein 2 (IGFBP-2) has been implicated in the pathophysiology of neoplasia. The PI3K/AKT/mTOR pathway has recently been shown to be a predominant regulator of IGFBP-2 at the protein level in MCF-7 breast cancer cells. However, there are gaps in knowledge with respect to the molecular mechanisms that underlie this regulation. Here, we show that the PI3K/AKT/mTOR pathway regulates IGFBP-2 protein levels by modulating IGFBP-2 mRNA abundance in MCF-7 cells. This change is achieved by regulating transcription through a critical region present in the first 200 bp upstream of the transcription initiation site where Sp1 transcription factor binds and drives transcription. IGF-1 treatment leads to increased nuclear abundance of Sp1 and increased IGFBP-2 mRNA and protein levels. Rapamycin and LY294002 induce a decline in Sp1 nuclear abundance and IGFBP-2 mRNA and protein levels. This work provides a mechanistic explanation for the observed effects of the PI3K/AKT/mTOR pathway on IGFBP-2 levels in MCF-7 cells. | lld:pubmed |
| pubmed-article:20370577 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20370577 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20370577 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20370577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20370577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20370577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20370577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20370577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20370577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20370577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20370577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20370577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20370577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20370577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20370577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20370577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20370577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20370577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20370577 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20370577 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:20370577 | pubmed:issn | 1029-2292 | lld:pubmed |
| pubmed-article:20370577 | pubmed:author | pubmed-author:PollakMichael... | lld:pubmed |
| pubmed-article:20370577 | pubmed:author | pubmed-author:DarnelAndrewA | lld:pubmed |
| pubmed-article:20370577 | pubmed:author | pubmed-author:MireutaMateiM | lld:pubmed |
| pubmed-article:20370577 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20370577 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:20370577 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20370577 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20370577 | pubmed:pagination | 243-55 | lld:pubmed |
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| pubmed-article:20370577 | pubmed:meshHeading | pubmed-meshheading:20370577... | lld:pubmed |
| pubmed-article:20370577 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20370577 | pubmed:articleTitle | IGFBP-2 expression in MCF-7 cells is regulated by the PI3K/AKT/mTOR pathway through Sp1-induced increase in transcription. | lld:pubmed |
| pubmed-article:20370577 | pubmed:affiliation | Departments of Medicine and Oncology, Lady Davis Institute for Medical Research, Montreal SMBD Jewish General Hospital, and McGill University, Montreal, Quebec, CanadaH3T 1E2. | lld:pubmed |
| pubmed-article:20370577 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:3485 | entrezgene:pubmed | pubmed-article:20370577 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20370577 | lld:entrezgene |
