| pubmed-article:20363327 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20363327 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:20363327 | lifeskim:mentions | umls-concept:C1413058 | lld:lifeskim |
| pubmed-article:20363327 | lifeskim:mentions | umls-concept:C0596235 | lld:lifeskim |
| pubmed-article:20363327 | lifeskim:mentions | umls-concept:C1709059 | lld:lifeskim |
| pubmed-article:20363327 | lifeskim:mentions | umls-concept:C0439799 | lld:lifeskim |
| pubmed-article:20363327 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20363327 | pubmed:dateCreated | 2010-5-31 | lld:pubmed |
| pubmed-article:20363327 | pubmed:abstractText | Neurotransmitter release and spontaneous action potentials during cochlear inner hair cell (IHC) development depend on the activity of Ca(v)1.3 voltage-gated L-type Ca(2+) channels. Their voltage- and Ca(2+)-dependent inactivation kinetics are slower than in other tissues but the underlying molecular mechanisms are not yet understood. We found that Rab3-interacting molecule-2alpha (RIM2alpha) mRNA is expressed in immature cochlear IHCs and the protein co-localizes with Ca(v)1.3 in the same presynaptic compartment of IHCs. Expression of RIM proteins in tsA-201 cells revealed binding to the beta-subunit of the channel complex and RIM-induced slowing of both Ca(2+)- and voltage-dependent inactivation of Ca(v)1.3 channels. By inhibiting inactivation, RIM induced a non-inactivating current component typical for IHC Ca(v)1.3 currents which should allow these channels to carry a substantial window current during prolonged depolarizations. These data suggest that RIM2 contributes to the stabilization of Ca(v)1.3 gating kinetics in immature IHCs. | lld:pubmed |
| pubmed-article:20363327 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20363327 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20363327 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20363327 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20363327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20363327 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20363327 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20363327 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:20363327 | pubmed:issn | 1095-9327 | lld:pubmed |
| pubmed-article:20363327 | pubmed:author | pubmed-author:KoschakAlexan... | lld:pubmed |
| pubmed-article:20363327 | pubmed:author | pubmed-author:StriessnigJör... | lld:pubmed |
| pubmed-article:20363327 | pubmed:author | pubmed-author:KnipperMarlie... | lld:pubmed |
| pubmed-article:20363327 | pubmed:author | pubmed-author:EngelJuttaJ | lld:pubmed |
| pubmed-article:20363327 | pubmed:author | pubmed-author:ObermairGeral... | lld:pubmed |
| pubmed-article:20363327 | pubmed:author | pubmed-author:Trockenbacher... | lld:pubmed |
| pubmed-article:20363327 | pubmed:author | pubmed-author:GebhartMathia... | lld:pubmed |
| pubmed-article:20363327 | pubmed:author | pubmed-author:BrandtNielsN | lld:pubmed |
| pubmed-article:20363327 | pubmed:author | pubmed-author:ZuccottiAnnal... | lld:pubmed |
| pubmed-article:20363327 | pubmed:author | pubmed-author:KaurGurjotG | lld:pubmed |
| pubmed-article:20363327 | pubmed:author | pubmed-author:Juhasz-Vedres... | lld:pubmed |
| pubmed-article:20363327 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20363327 | pubmed:volume | 44 | lld:pubmed |
| pubmed-article:20363327 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20363327 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20363327 | pubmed:pagination | 246-59 | lld:pubmed |
| pubmed-article:20363327 | pubmed:dateRevised | 2011-4-6 | lld:pubmed |
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| pubmed-article:20363327 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20363327 | pubmed:articleTitle | Modulation of Cav1.3 Ca2+ channel gating by Rab3 interacting molecule. | lld:pubmed |
| pubmed-article:20363327 | pubmed:affiliation | Institute of Pharmacy, Pharmacology and Toxicology, University of Innsbruck, Peter-Mayr-Strasse 1/I, A-6020 Innsbruck, Austria; Center of Molecular Biosciences Innsbruck (CMBI), Innsbruck, Austria. | lld:pubmed |
| pubmed-article:20363327 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20363327 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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