| pubmed-article:20348097 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20348097 | lifeskim:mentions | umls-concept:C0679729 | lld:lifeskim |
| pubmed-article:20348097 | lifeskim:mentions | umls-concept:C0279516 | lld:lifeskim |
| pubmed-article:20348097 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:20348097 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:20348097 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20348097 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:20348097 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:20348097 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:20348097 | lifeskim:mentions | umls-concept:C0766850 | lld:lifeskim |
| pubmed-article:20348097 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:20348097 | pubmed:dateCreated | 2010-5-17 | lld:pubmed |
| pubmed-article:20348097 | pubmed:abstractText | Intracellular bacteria cause serious infectious diseases such as tuberculosis, shigellosis, and listeriosis. The Drosophila peptidoglycan recognition protein (PGRP)-LE functions as an important host pattern recognition receptor against intracellular bacteria such as Listeria monocytogenes. One PGRP-LE-mediated intracellular response against L. monocytogenes infection is the induction of autophagy, a conserved intracellular degradation system. Here, to further elucidate PGRP-LE-mediated intracellular innate immune responses, we performed a strategic microarray analysis and identified the Listericin gene, whose expression is induced in response to L. monocytogenes infection in a PGRP-LE-dependent manner. RNA interference and overexpression experiments demonstrated that Listericin gene induction is cooperatively regulated by PGRP-LE and the JAK-STAT (Janus kinase-signal transducers and activators of transcription) pathway. An in vitro cell culture assay showed that Listericin is secreted as processed forms and suppresses the growth of L. monocytogenes and Gram-negative bacteria. A colony formation unit assay clearly demonstrated that induction of the Listericin gene suppresses not only the growth of L. monocytogenes but also the growth of Gram-negative bacteria in vivo. Based on these findings, we propose that the Listericin gene encodes a novel antibacterial peptide-like protein whose induction is cooperatively regulated by PGRP-LE and the JAK-STAT pathway. | lld:pubmed |
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| pubmed-article:20348097 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20348097 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20348097 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20348097 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20348097 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20348097 | pubmed:month | May | lld:pubmed |
| pubmed-article:20348097 | pubmed:issn | 1083-351X | lld:pubmed |
| pubmed-article:20348097 | pubmed:author | pubmed-author:KurataShoichi... | lld:pubmed |
| pubmed-article:20348097 | pubmed:author | pubmed-author:OshimaYoshite... | lld:pubmed |
| pubmed-article:20348097 | pubmed:author | pubmed-author:GotoAkiraA | lld:pubmed |
| pubmed-article:20348097 | pubmed:author | pubmed-author:YanoTamakiT | lld:pubmed |
| pubmed-article:20348097 | pubmed:author | pubmed-author:TerashimaJunJ | lld:pubmed |
| pubmed-article:20348097 | pubmed:author | pubmed-author:IwashitaShinz... | lld:pubmed |
| pubmed-article:20348097 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20348097 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:20348097 | pubmed:volume | 285 | lld:pubmed |
| pubmed-article:20348097 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20348097 | pubmed:authorsComplete | Y | lld:pubmed |
