| pubmed-article:20345476 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20345476 | lifeskim:mentions | umls-concept:C0280325 | lld:lifeskim |
| pubmed-article:20345476 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:20345476 | lifeskim:mentions | umls-concept:C0085862 | lld:lifeskim |
| pubmed-article:20345476 | lifeskim:mentions | umls-concept:C1299583 | lld:lifeskim |
| pubmed-article:20345476 | lifeskim:mentions | umls-concept:C1424222 | lld:lifeskim |
| pubmed-article:20345476 | lifeskim:mentions | umls-concept:C1514475 | lld:lifeskim |
| pubmed-article:20345476 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:20345476 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:20345476 | lifeskim:mentions | umls-concept:C1608386 | lld:lifeskim |
| pubmed-article:20345476 | lifeskim:mentions | umls-concept:C1549571 | lld:lifeskim |
| pubmed-article:20345476 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:20345476 | pubmed:dateCreated | 2010-6-10 | lld:pubmed |
| pubmed-article:20345476 | pubmed:abstractText | DJ-1 is frequently overexpressed in a large variety of solid tumors, but the DJ-1 expression in laryngeal squamous cell cancer and its clinical/prognostic significance is unclear. We aimed to evaluate DJ-1 protein expression in glottic squamous cell carcinoma (GSCC) and to correlate this with clinicopathological data including patient survival. The expression of DJ-1 in GSCCs (60) and adjacent normal tissue (44) was assessed by immunohistochemistry and western blot analysis. In addition, the role of DJ-1 was investigated in tumorigenesis by transfecting DJ1-specific siRNA into laryngeal squamous cell carcinoma (LSCC) Hep-2 cells. Our data showed that positive expression of DJ-1 was found in 85% of GSCCs. In univariate survival analysis of the GSCC cohorts, a highly significant association between DJ-1 expression with shortened patient overall survival (5-year survival rate 92.9%vs 66.6%; P = 0.001; log rank test) was demonstrated. In multivariate analyses, DJ-1, tumor grading, and pT status were significant prognostic parameters for shortened patient overall survival. Furthermore, siRNA targeting DJ-1 can effectively inhibit DJ-1 expression, resulting in enhanced apoptosis and less proliferation of Hep-2 cells. We concluded that DJ-1 overexpression might be a novel independent molecular marker for poor prognosis (shortened overall survival) of patients with GSCC. | lld:pubmed |
| pubmed-article:20345476 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20345476 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20345476 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20345476 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20345476 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20345476 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20345476 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20345476 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20345476 | pubmed:month | May | lld:pubmed |
| pubmed-article:20345476 | pubmed:issn | 1349-7006 | lld:pubmed |
| pubmed-article:20345476 | pubmed:author | pubmed-author:WangZhang-Fen... | lld:pubmed |
| pubmed-article:20345476 | pubmed:author | pubmed-author:JiangHong-Yan... | lld:pubmed |
| pubmed-article:20345476 | pubmed:author | pubmed-author:LeiWen-BinWB | lld:pubmed |
| pubmed-article:20345476 | pubmed:author | pubmed-author:ZhuangHui-Wen... | lld:pubmed |
| pubmed-article:20345476 | pubmed:author | pubmed-author:WenWei-PingWP | lld:pubmed |
| pubmed-article:20345476 | pubmed:author | pubmed-author:ZhuXiao-LinXL | lld:pubmed |
| pubmed-article:20345476 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20345476 | pubmed:volume | 101 | lld:pubmed |
| pubmed-article:20345476 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20345476 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20345476 | pubmed:pagination | 1320-5 | lld:pubmed |
| pubmed-article:20345476 | pubmed:meshHeading | pubmed-meshheading:20345476... | lld:pubmed |
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| pubmed-article:20345476 | pubmed:meshHeading | pubmed-meshheading:20345476... | lld:pubmed |
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| pubmed-article:20345476 | pubmed:meshHeading | pubmed-meshheading:20345476... | lld:pubmed |
| pubmed-article:20345476 | pubmed:meshHeading | pubmed-meshheading:20345476... | lld:pubmed |
| pubmed-article:20345476 | pubmed:meshHeading | pubmed-meshheading:20345476... | lld:pubmed |
| pubmed-article:20345476 | pubmed:meshHeading | pubmed-meshheading:20345476... | lld:pubmed |
| pubmed-article:20345476 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20345476 | pubmed:articleTitle | DJ-1: a novel independent prognostic marker for survival in glottic squamous cell carcinoma. | lld:pubmed |
| pubmed-article:20345476 | pubmed:affiliation | Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital, Guangzhou, China. | lld:pubmed |
| pubmed-article:20345476 | pubmed:publicationType | Journal Article | lld:pubmed |
