| pubmed-article:20338826 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20338826 | lifeskim:mentions | umls-concept:C0037929 | lld:lifeskim |
| pubmed-article:20338826 | lifeskim:mentions | umls-concept:C1185739 | lld:lifeskim |
| pubmed-article:20338826 | lifeskim:mentions | umls-concept:C0458247 | lld:lifeskim |
| pubmed-article:20338826 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:20338826 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:20338826 | lifeskim:mentions | umls-concept:C0021149 | lld:lifeskim |
| pubmed-article:20338826 | lifeskim:mentions | umls-concept:C1883709 | lld:lifeskim |
| pubmed-article:20338826 | lifeskim:mentions | umls-concept:C0332514 | lld:lifeskim |
| pubmed-article:20338826 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:20338826 | pubmed:dateCreated | 2010-8-30 | lld:pubmed |
| pubmed-article:20338826 | pubmed:abstractText | Approximately 70% of male rats receiving severe T8 spinal contusions develop allodynia in T5-7 dermatomes (at-level) beginning 2 weeks after injury. In contrast, rats having either complete transections or dorsal hemisections do not develop allodynia at-level after chronic spinal cord injury (SCI). In the present study, incomplete laceration and contusion injuries were made to test for neuroanatomical correlates between areas of white matter damage/sparing at the lesion epicenter and the presence/absence of allodynia. After incomplete laceration lesions and 6 weeks of behavioral testing, histological reconstruction and analysis of the lesion epicenters revealed a significant difference (P < .001) in the amount of ventrolateral funiculus (VLF) asymmetry between rats showing pain-like responses evoked by touch (74.5% +/- 8.4% side-to-side difference in VLF damage) versus those not responding to touch (11.3% +/- 4.4% side-to-side difference in VLF damage). A 5-week mean allodynia score for each rat that incorporates a full range of forces that are all innocuous in intact controls revealed that the degree of hypersensitivity at level is related to the extent of VLF asymmetry after SCI. No other damaged spinal white matter or gray matter area was correlated with sensitivity to touch. Similar findings were obtained for rats receiving T8 contusions, a more clinically relevant injury. These data suggest that different extents of damage/sparing between the 2 sides of VLF probably are a requisite for the development of allodynia after SCI. PERSPECTIVE: A side-to-side lesion asymmetry after chronic SCI in a rodent model was found to be highly correlated with the presence and degree of allodynia. Greater insight of key factors contributing to the development and maintenance of chronic neuropathic pain is important for improving quality of life. | lld:pubmed |
| pubmed-article:20338826 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20338826 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20338826 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20338826 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20338826 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:20338826 | pubmed:issn | 1528-8447 | lld:pubmed |
| pubmed-article:20338826 | pubmed:author | pubmed-author:HubscherCharl... | lld:pubmed |
| pubmed-article:20338826 | pubmed:author | pubmed-author:GuptaDaya SDS | lld:pubmed |
| pubmed-article:20338826 | pubmed:author | pubmed-author:VukmanicEric... | lld:pubmed |
| pubmed-article:20338826 | pubmed:author | pubmed-author:ArmstrongJame... | lld:pubmed |
| pubmed-article:20338826 | pubmed:author | pubmed-author:FellJason DJD | lld:pubmed |
| pubmed-article:20338826 | pubmed:author | pubmed-author:HallBradley... | lld:pubmed |
| pubmed-article:20338826 | pubmed:author | pubmed-author:LallyJason... | lld:pubmed |
| pubmed-article:20338826 | pubmed:copyrightInfo | Copyright 2010 American Pain Society. Published by Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20338826 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20338826 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:20338826 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20338826 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20338826 | pubmed:pagination | 864-75 | lld:pubmed |
| pubmed-article:20338826 | pubmed:dateRevised | 2011-9-13 | lld:pubmed |
| pubmed-article:20338826 | pubmed:meshHeading | pubmed-meshheading:20338826... | lld:pubmed |
| pubmed-article:20338826 | pubmed:meshHeading | pubmed-meshheading:20338826... | lld:pubmed |
| pubmed-article:20338826 | pubmed:meshHeading | pubmed-meshheading:20338826... | lld:pubmed |
| pubmed-article:20338826 | pubmed:meshHeading | pubmed-meshheading:20338826... | lld:pubmed |
| pubmed-article:20338826 | pubmed:meshHeading | pubmed-meshheading:20338826... | lld:pubmed |
| pubmed-article:20338826 | pubmed:meshHeading | pubmed-meshheading:20338826... | lld:pubmed |
