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pubmed-article:20337187pubmed:abstractTextNarcolepsy with cataplexy is caused by a loss of orexin (hypocretin) signaling, but the physiologic mechanisms that result in poor maintenance of wakefulness and fragmented sleep remain unknown. Conventional scoring of sleep cannot reveal much about the process of transitioning between states or the variations within states. We developed an EEG spectral analysis technique to determine whether the state instability in a mouse model of narcolepsy reflects abnormal sleep or wake states, faster movements between states, or abnormal transitions between states.lld:pubmed
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pubmed-article:20337187pubmed:articleTitleAbnormal sleep/wake dynamics in orexin knockout mice.lld:pubmed
pubmed-article:20337187pubmed:affiliationDepartment of Neurology, Beth Israel Deaconess Medical Center Boston, MA, USA. cdbehn@umich.edulld:pubmed
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