| pubmed-article:2032229 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2032229 | lifeskim:mentions | umls-concept:C0015780 | lld:lifeskim |
| pubmed-article:2032229 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:2032229 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2032229 | lifeskim:mentions | umls-concept:C0048629 | lld:lifeskim |
| pubmed-article:2032229 | lifeskim:mentions | umls-concept:C0600686 | lld:lifeskim |
| pubmed-article:2032229 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:2032229 | pubmed:dateCreated | 1991-6-21 | lld:pubmed |
| pubmed-article:2032229 | pubmed:abstractText | The comparative carcinogenicities of N-hydroxy-N-acetyl-1-aminopyrene, N-acetyl-1-aminopyrene, and 1-, 2-, and 4-nitropyrene were determined following i.p. injection into weaning female CD rats (67 mumol/kg body weight in dimethyl sulfoxide; 3 times/week for 4 weeks). At sacrifice 61 weeks after the first injection the incidences of malignant mammary tumors were increased significantly to 45 and 24% in the 4-nitropyrene- and N-hydroxy-N-acetyl-2-aminofluorene-treated groups, respectively. Cellular altered foci in the liver were increased significantly in the N-acetyl-1-aminopyrene-, N-hydroxy-N-acetyl-1-aminopyrene-, and N-hydroxy-N-acetyl-2-aminofluorene- treated groups; the latter two compounds also led to significantly increased formation of hyperplastic nodules in this organ. Significant increases in leukemia induction were observed in animals treated with 2-nitropyrene or N-hydroxy-N-acetyl-2-aminofluorene. In an experiment designed to compare the influence of the route of administration on the carcinogenic potential of this agent, 1-nitropyrene was injected i.p. or s.c. into weanling female CD rats (100 mumol/kg body weight; once a week for 4 weeks). The animals were sacrificed at 87 to 90 weeks after the first treatment. The incidences of mammary gland tumors in animals receiving injections of 1-nitropyrene by either route (59%) were significantly higher than in solvent-injected controls (37%). The incidences of adenocarcinoma in the i.p. 1-nitropyrene group (28%) and fibroadenoma in the s.c. 1-nitropyrene group (52%) were significantly higher than in the control animals (7 and 27%, respectively). These data suggest that the demonstration of the weak carcinogenicity of 1-nitropyrene is probably more a function of the length of the observation period than of the routes of administration used here. A further exploration of the effect of the route of administration involved treatment of weanling female CD rats by direct injection of 1-, 2-, or 4-nitropyrene into the mammary fat pads. A total of 2.04 mumol of the nitrocompound in dimethyl sulfoxide was injected into the mammary glands under each of the 6 left nipples. The right mammary glands were treated with the solvent only. Injections of the thoracic nipple areas were carried out on day 1; inguinal areas were treated on day 2. The animals were sacrificed after 77 weeks. The number of mammary tumor-bearing animals (23 of 28), the number with fibroadenoma (15 of 28), and the number with adenocarcinoma (19 of 28) were significantly increased in the 4-nitropyrene-treated group as compared with animals treated with only dimethyl sulfoxide.(ABSTRACT TRUNCATED AT 400 WORDS) | lld:pubmed |
| pubmed-article:2032229 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2032229 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2032229 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2032229 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2032229 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2032229 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2032229 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2032229 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2032229 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2032229 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2032229 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:2032229 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:2032229 | pubmed:author | pubmed-author:KingC MCM | lld:pubmed |
| pubmed-article:2032229 | pubmed:author | pubmed-author:LeeM SMS | lld:pubmed |
| pubmed-article:2032229 | pubmed:author | pubmed-author:WangC YCY | lld:pubmed |
| pubmed-article:2032229 | pubmed:author | pubmed-author:HiroseMM | lld:pubmed |
| pubmed-article:2032229 | pubmed:author | pubmed-author:TarEE | lld:pubmed |
| pubmed-article:2032229 | pubmed:author | pubmed-author:ImaidaKK | lld:pubmed |
| pubmed-article:2032229 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2032229 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2032229 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:2032229 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2032229 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2032229 | pubmed:pagination | 2902-7 | lld:pubmed |
| pubmed-article:2032229 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:2032229 | pubmed:meshHeading | pubmed-meshheading:2032229-... | lld:pubmed |
| pubmed-article:2032229 | pubmed:meshHeading | pubmed-meshheading:2032229-... | lld:pubmed |
| pubmed-article:2032229 | pubmed:meshHeading | pubmed-meshheading:2032229-... | lld:pubmed |
| pubmed-article:2032229 | pubmed:meshHeading | pubmed-meshheading:2032229-... | lld:pubmed |
| pubmed-article:2032229 | pubmed:meshHeading | pubmed-meshheading:2032229-... | lld:pubmed |
| pubmed-article:2032229 | pubmed:meshHeading | pubmed-meshheading:2032229-... | lld:pubmed |
| pubmed-article:2032229 | pubmed:meshHeading | pubmed-meshheading:2032229-... | lld:pubmed |
| pubmed-article:2032229 | pubmed:meshHeading | pubmed-meshheading:2032229-... | lld:pubmed |
| pubmed-article:2032229 | pubmed:meshHeading | pubmed-meshheading:2032229-... | lld:pubmed |
| pubmed-article:2032229 | pubmed:meshHeading | pubmed-meshheading:2032229-... | lld:pubmed |
| pubmed-article:2032229 | pubmed:meshHeading | pubmed-meshheading:2032229-... | lld:pubmed |
| pubmed-article:2032229 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2032229 | pubmed:articleTitle | Comparative carcinogenicities of 1-, 2-, and 4-nitropyrene and structurally related compounds in the female CD rat. | lld:pubmed |
| pubmed-article:2032229 | pubmed:affiliation | Department of Chemical Carcinogenesis, Michigan Cancer Foundation, Detroit 48201. | lld:pubmed |
| pubmed-article:2032229 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2032229 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:2032229 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2032229 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:2032229 | lld:pubmed |
