| pubmed-article:20303771 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20303771 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:20303771 | lifeskim:mentions | umls-concept:C0039921 | lld:lifeskim |
| pubmed-article:20303771 | lifeskim:mentions | umls-concept:C0255998 | lld:lifeskim |
| pubmed-article:20303771 | lifeskim:mentions | umls-concept:C0243076 | lld:lifeskim |
| pubmed-article:20303771 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:20303771 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:20303771 | lifeskim:mentions | umls-concept:C0243072 | lld:lifeskim |
| pubmed-article:20303771 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:20303771 | pubmed:dateCreated | 2010-4-5 | lld:pubmed |
| pubmed-article:20303771 | pubmed:abstractText | Novel thiazolotriazolopyrimidine derivatives (23-33) designed as potential adenosine A(2A) receptor (A(2A)R) antagonists were synthesized. Molecular docking studies revealed that all compounds (23-33) exhibited strong interaction with A(2A)R. The strong interaction of the compounds (23-33) with A(2A)R in silico was confirmed by their high binding affinity with human A(2A)R stably expressed in HEK293 cells using radioligand-binding assay. The compounds 24-26 demonstrated substantial binding affinity and selectivity for A(2A)R as compared to SCH58261, a standard A(2A)R antagonist. Decrease in A(2A)R-coupled release of endogenous cAMP in treated HEK293 cells demonstrated in vitro A(2A)R antagonist potential of the compounds 24-26. Attenuation in haloperidol-induced motor impairments (catalepsy and akinesia) in Swiss albino male mice pre-treated with compounds 24-26 further supports their role in the alleviation of PD symptoms. | lld:pubmed |
| pubmed-article:20303771 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20303771 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20303771 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20303771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20303771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20303771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20303771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20303771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20303771 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20303771 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20303771 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:20303771 | pubmed:issn | 1464-3391 | lld:pubmed |
| pubmed-article:20303771 | pubmed:author | pubmed-author:BarodiaSandee... | lld:pubmed |
| pubmed-article:20303771 | pubmed:author | pubmed-author:LuthraPratibh... | lld:pubmed |
| pubmed-article:20303771 | pubmed:author | pubmed-author:PrakashAmresh... | lld:pubmed |
| pubmed-article:20303771 | pubmed:author | pubmed-author:MishraChandra... | lld:pubmed |
| pubmed-article:20303771 | pubmed:author | pubmed-author:Senthil... | lld:pubmed |
| pubmed-article:20303771 | pubmed:copyrightInfo | Copyright 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20303771 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20303771 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:20303771 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:20303771 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20303771 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20303771 | pubmed:pagination | 2491-500 | lld:pubmed |
| pubmed-article:20303771 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:20303771 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20303771 | pubmed:articleTitle | Novel 8-(furan-2-yl)-3-substituted thiazolo [5,4-e][1,2,4] triazolo[1,5-c] pyrimidine-2(3H)-thione derivatives as potential adenosine A(2A) receptor antagonists. | lld:pubmed |
| pubmed-article:20303771 | pubmed:affiliation | Medicinal Chemistry Division, Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, North Campus, Mall Road, Delhi 110 007, India. | lld:pubmed |
| pubmed-article:20303771 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20303771 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:20303771 | lld:chembl |
