| pubmed-article:20302595 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20302595 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:20302595 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:20302595 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:20302595 | lifeskim:mentions | umls-concept:C0023884 | lld:lifeskim |
| pubmed-article:20302595 | lifeskim:mentions | umls-concept:C0037995 | lld:lifeskim |
| pubmed-article:20302595 | lifeskim:mentions | umls-concept:C0678861 | lld:lifeskim |
| pubmed-article:20302595 | lifeskim:mentions | umls-concept:C0332161 | lld:lifeskim |
| pubmed-article:20302595 | lifeskim:mentions | umls-concept:C0038952 | lld:lifeskim |
| pubmed-article:20302595 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:20302595 | pubmed:dateCreated | 2010-11-5 | lld:pubmed |
| pubmed-article:20302595 | pubmed:abstractText | Prevention of acute portal hyperperfusion in small-for-size livers by inflow modulation results in beneficial postoperative outcome. The objective of this study was to unravel the underlying mechanism, emphasizing the intimate relationship between portal venous (PV) and hepatic arterial (HA) blood flow (BF). Rats underwent partial hepatectomy (pHx), splenectomy before pHx or splenectomy and ligation of the A. hepatica before pHx. Portal venous blood flow (PVBF), hepatic arterial blood flow (HABF), and tissue pO? were assessed during stepwise resection from 30% to 90%. Hepatic regeneration and hypoxia-responsive gene expression were analyzed in each group after nonlethal 85% pHx. 90% pHx caused a fourfold rise in PVBF, a slight decrease in HABF with a 50% reduction in pO?, and high mortality. Splenectomy before pHx reduced the PVBF and caused a rise in HABF with doubling in tissue pO?. An attenuation of hypoxia-responsive gene expression turned into enhanced hepatocellular regeneration and improved survival. A. hepatica ligation abolished the beneficial effect of splenectomy on tissue oxygenation, proliferation, and outcome. In conclusion, the beneficial effect of splenectomy in small-for-size livers can be attributed to a rise in HABF with sufficient oxygen supply rather than to a reduced portal venous hyperperfusion to the remnant liver. | lld:pubmed |
| pubmed-article:20302595 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20302595 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20302595 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20302595 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20302595 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20302595 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20302595 | pubmed:issn | 1432-2277 | lld:pubmed |
| pubmed-article:20302595 | pubmed:author | pubmed-author:MengerMichael... | lld:pubmed |
| pubmed-article:20302595 | pubmed:author | pubmed-author:VollmarBrigit... | lld:pubmed |
| pubmed-article:20302595 | pubmed:author | pubmed-author:EipelChristia... | lld:pubmed |
| pubmed-article:20302595 | pubmed:author | pubmed-author:AbshagenKerst... | lld:pubmed |
| pubmed-article:20302595 | pubmed:author | pubmed-author:CantréDanielD | lld:pubmed |
| pubmed-article:20302595 | pubmed:author | pubmed-author:RitterJessica... | lld:pubmed |
| pubmed-article:20302595 | pubmed:copyrightInfo | © 2010 The Authors. Journal compilation © 2010 European Society for Organ Transplantation. | lld:pubmed |
| pubmed-article:20302595 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20302595 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:20302595 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20302595 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20302595 | pubmed:pagination | 998-1007 | lld:pubmed |
| pubmed-article:20302595 | pubmed:meshHeading | pubmed-meshheading:20302595... | lld:pubmed |
| pubmed-article:20302595 | pubmed:meshHeading | pubmed-meshheading:20302595... | lld:pubmed |
| pubmed-article:20302595 | pubmed:meshHeading | pubmed-meshheading:20302595... | lld:pubmed |
| pubmed-article:20302595 | pubmed:meshHeading | pubmed-meshheading:20302595... | lld:pubmed |
| pubmed-article:20302595 | pubmed:meshHeading | pubmed-meshheading:20302595... | lld:pubmed |
| pubmed-article:20302595 | pubmed:meshHeading | pubmed-meshheading:20302595... | lld:pubmed |
| pubmed-article:20302595 | pubmed:meshHeading | pubmed-meshheading:20302595... | lld:pubmed |
| pubmed-article:20302595 | pubmed:meshHeading | pubmed-meshheading:20302595... | lld:pubmed |
| pubmed-article:20302595 | pubmed:meshHeading | pubmed-meshheading:20302595... | lld:pubmed |
| pubmed-article:20302595 | pubmed:meshHeading | pubmed-meshheading:20302595... | lld:pubmed |
| pubmed-article:20302595 | pubmed:meshHeading | pubmed-meshheading:20302595... | lld:pubmed |
| pubmed-article:20302595 | pubmed:meshHeading | pubmed-meshheading:20302595... | lld:pubmed |
| pubmed-article:20302595 | pubmed:meshHeading | pubmed-meshheading:20302595... | lld:pubmed |
| pubmed-article:20302595 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20302595 | pubmed:articleTitle | Splenectomy improves survival by increasing arterial blood supply in a rat model of reduced-size liver. | lld:pubmed |
| pubmed-article:20302595 | pubmed:affiliation | Institute for Experimental Surgery, University of Rostock, Rostock, Germany. eipel@uni-rostock.de | lld:pubmed |
| pubmed-article:20302595 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20302595 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20302595 | lld:pubmed |
