| pubmed-article:20299596 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20299596 | lifeskim:mentions | umls-concept:C0162429 | lld:lifeskim |
| pubmed-article:20299596 | lifeskim:mentions | umls-concept:C0023185 | lld:lifeskim |
| pubmed-article:20299596 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:20299596 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:20299596 | lifeskim:mentions | umls-concept:C0034011 | lld:lifeskim |
| pubmed-article:20299596 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:20299596 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:20299596 | lifeskim:mentions | umls-concept:C1511545 | lld:lifeskim |
| pubmed-article:20299596 | pubmed:issue | 5972 | lld:pubmed |
| pubmed-article:20299596 | pubmed:dateCreated | 2010-3-19 | lld:pubmed |
| pubmed-article:20299596 | pubmed:abstractText | The onset of puberty defines a developmental stage when some learning processes are diminished, but the mechanism for this deficit remains unknown. We found that, at puberty, expression of inhibitory alpha4betadelta gamma-aminobutyric acid type A (GABAA) receptors (GABAR) increases perisynaptic to excitatory synapses in CA1 hippocampus. Shunting inhibition via these receptors reduced N-methyl-D-aspartate receptor activation, impairing induction of long-term potentiation (LTP). Pubertal mice also failed to learn a hippocampal, LTP-dependent spatial task that was easily acquired by delta-/- mice. However, the stress steroid THP (3alphaOH-5alpha[beta]-pregnan-20-one), which reduces tonic inhibition at puberty, facilitated learning. Thus, the emergence of alpha4betadelta GABARs at puberty impairs learning, an effect that can be reversed by a stress steroid. | lld:pubmed |
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| pubmed-article:20299596 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20299596 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20299596 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20299596 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20299596 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20299596 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:20299596 | pubmed:author | pubmed-author:ShenHuiH | lld:pubmed |
| pubmed-article:20299596 | pubmed:author | pubmed-author:AokiChiyeC | lld:pubmed |
| pubmed-article:20299596 | pubmed:author | pubmed-author:SmithSheryl... | lld:pubmed |
| pubmed-article:20299596 | pubmed:author | pubmed-author:FentonAndré... | lld:pubmed |
| pubmed-article:20299596 | pubmed:author | pubmed-author:StelzerArminA | lld:pubmed |
| pubmed-article:20299596 | pubmed:author | pubmed-author:SabaliauskasN... | lld:pubmed |
| pubmed-article:20299596 | pubmed:author | pubmed-author:SherpaAngA | lld:pubmed |
| pubmed-article:20299596 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20299596 | pubmed:day | 19 | lld:pubmed |
| pubmed-article:20299596 | pubmed:volume | 327 | lld:pubmed |
| pubmed-article:20299596 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20299596 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20299596 | pubmed:pagination | 1515-8 | lld:pubmed |
| pubmed-article:20299596 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
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