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pubmed-article:20299158pubmed:issue9lld:pubmed
pubmed-article:20299158pubmed:dateCreated2010-9-17lld:pubmed
pubmed-article:20299158pubmed:abstractTextBody weight development is closely regulated by central nervous mechanisms. As has been demonstrated recently, the capability of the brain to actively demand energy from the body (brain-pull) is indispensable for the maintenance of systemic homeostasis. A deficit in this brain-pull may result in compensatory ingestive behavior followed by weight gain in the medium or long term. The aim of this study was to establish a biomarker of such an incompetent brain-pull. Since lactate is an alternative cerebral energy substrate to glucose, we investigated whether low fasting plasma lactate concentrations are associated with weight gain and increased feelings of hunger in patients with type 2 diabetes over a 3-year period.lld:pubmed
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pubmed-article:20299158pubmed:copyrightInfoCopyright © 2010 Elsevier Ltd. All rights reserved.lld:pubmed
pubmed-article:20299158pubmed:issnTypeElectroniclld:pubmed
pubmed-article:20299158pubmed:volume35lld:pubmed
pubmed-article:20299158pubmed:ownerNLMlld:pubmed
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pubmed-article:20299158pubmed:pagination1287-93lld:pubmed
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pubmed-article:20299158pubmed:year2010lld:pubmed
pubmed-article:20299158pubmed:articleTitleLow plasma lactate concentration as a biomarker of an incompetent brain-pull: a risk factor for weight gain in type 2 diabetes patients.lld:pubmed
pubmed-article:20299158pubmed:affiliationMedical Clinic I , University of Luebeck, Luebeck, Germany.lld:pubmed
pubmed-article:20299158pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20299158pubmed:publicationTypeClinical Triallld:pubmed
pubmed-article:20299158pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed