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| pubmed-article:2024961 | lifeskim:mentions | umls-concept:C1272753 | lld:lifeskim |
| pubmed-article:2024961 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:2024961 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:2024961 | lifeskim:mentions | umls-concept:C0026336 | lld:lifeskim |
| pubmed-article:2024961 | lifeskim:mentions | umls-concept:C0199176 | lld:lifeskim |
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| pubmed-article:2024961 | lifeskim:mentions | umls-concept:C0658114 | lld:lifeskim |
| pubmed-article:2024961 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:2024961 | pubmed:dateCreated | 1991-5-31 | lld:pubmed |
| pubmed-article:2024961 | pubmed:abstractText | Three 8-aminoquinolines from the Walter Reed Army Institute for Research (WRAIR), WR6026, WR238605, and WR242511, strongly inhibited Pneumocystis carinii growth in vitro at 1 microgram/ml. This activity was similar to that of primaquine. In rat therapy models, the WRAIR compounds affected Pneumocystis pneumonia at doses as low as 0.25 mg/kg (WR242511) or 0.5 mg/kg (WR6026 and WR238605). At these doses, primaquine alone was ineffective as therapy. In a rat prophylaxis model, all three WRAIR 8-aminoquinolines were extremely effective at daily doses of 0.57 mg/kg, showing activity greater than that of primaquine at this dosage and comparable to that of trimethoprim-sulfamethoxazole at 50/250 mg/kg. | lld:pubmed |
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| pubmed-article:2024961 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2024961 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2024961 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:2024961 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2024961 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:2024961 | pubmed:issn | 0066-4804 | lld:pubmed |
| pubmed-article:2024961 | pubmed:author | pubmed-author:SmithJ WJW | lld:pubmed |
| pubmed-article:2024961 | pubmed:author | pubmed-author:TidwellR RRR | lld:pubmed |
| pubmed-article:2024961 | pubmed:author | pubmed-author:QueenerS FSF | lld:pubmed |
| pubmed-article:2024961 | pubmed:author | pubmed-author:BartlettM SMS | lld:pubmed |
| pubmed-article:2024961 | pubmed:author | pubmed-author:BermanJ DJD | lld:pubmed |
| pubmed-article:2024961 | pubmed:author | pubmed-author:MilhousW KWK | lld:pubmed |
| pubmed-article:2024961 | pubmed:author | pubmed-author:EllisW YWY | lld:pubmed |
| pubmed-article:2024961 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2024961 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:2024961 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2024961 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2024961 | pubmed:pagination | 277-82 | lld:pubmed |
| pubmed-article:2024961 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:2024961 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2024961 | pubmed:articleTitle | 8-Aminoquinolines from Walter Reed Army Institute for Research for treatment and prophylaxis of Pneumocystis pneumonia in rat models. | lld:pubmed |
| pubmed-article:2024961 | pubmed:affiliation | Indiana University School of Medicine, Indianapolis 46202-5120. | lld:pubmed |
| pubmed-article:2024961 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2024961 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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