| pubmed-article:2023915 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2023915 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:2023915 | lifeskim:mentions | umls-concept:C1882597 | lld:lifeskim |
| pubmed-article:2023915 | lifeskim:mentions | umls-concept:C0040690 | lld:lifeskim |
| pubmed-article:2023915 | lifeskim:mentions | umls-concept:C0042870 | lld:lifeskim |
| pubmed-article:2023915 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:2023915 | lifeskim:mentions | umls-concept:C0333562 | lld:lifeskim |
| pubmed-article:2023915 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:2023915 | lifeskim:mentions | umls-concept:C0301630 | lld:lifeskim |
| pubmed-article:2023915 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:2023915 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:2023915 | pubmed:dateCreated | 1991-5-31 | lld:pubmed |
| pubmed-article:2023915 | pubmed:abstractText | We demonstrated previously that implants of bone matrix prepared from vitamin D-deficient (-D) rats were less osteoinductive and contained less extractable mitogenic activity compared with control implants prepared from vitamin D-replete (+D) rats and proposed that bone from -D rats is deficient in one or more specific growth factors. To test this hypothesis, bones from rats that were fed either +D or -D diets and kept in the dark for 8 wk were extracted and assayed for insulin-like growth factors I and II (IGF-I and IGF-II) and transforming growth factor beta (TGF-beta), the three most abundant growth factors in rat bone, and osteocalcin. Serum calcium, 25-hydroxyvitamin D3 and 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] were determined at sacrifice. In -D rats, there were significant reductions in serum calcium, 25-hydroxyvitamin D3, and 1,25(OH)2D3 and skeletal TGF-beta but no differences in extractable skeletal protein, IGF-I, IGF-II, or osteocalcin compared with +D rats. To determine whether 1,25(OH)2D3 increased TGF-beta production by bone cells, we treated mouse calvaria for 6 days and mouse osteoblasts for 2 days with 10 nM 1,25(OH)2D3. Production of TGF-beta was increased almost 100% by 1,25(OH)2D3. We conclude that vitamin D deficiency reduces deposition of TGF-beta in rat bone and that diminished skeletal TGF-beta could contribute to the previously observed decrease in osteoinduction in implants from -D rat bone. The findings support the possibility that vitamin D and bone-derived TGF-beta are required for normal repair of the skeleton. | lld:pubmed |
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| pubmed-article:2023915 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2023915 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2023915 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2023915 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2023915 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2023915 | pubmed:month | May | lld:pubmed |
| pubmed-article:2023915 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:2023915 | pubmed:author | pubmed-author:MohanSS | lld:pubmed |
| pubmed-article:2023915 | pubmed:author | pubmed-author:BaylinkD JDJ | lld:pubmed |
| pubmed-article:2023915 | pubmed:author | pubmed-author:BellN HNH | lld:pubmed |
| pubmed-article:2023915 | pubmed:author | pubmed-author:LinkhartT ATA | lld:pubmed |
| pubmed-article:2023915 | pubmed:author | pubmed-author:FinkelmanR... | lld:pubmed |
| pubmed-article:2023915 | pubmed:author | pubmed-author:OTTE WEW | lld:pubmed |
| pubmed-article:2023915 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2023915 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:2023915 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:2023915 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2023915 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2023915 | pubmed:pagination | 3657-60 | lld:pubmed |
| pubmed-article:2023915 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2023915 | pubmed:meshHeading | pubmed-meshheading:2023915-... | lld:pubmed |
| pubmed-article:2023915 | pubmed:meshHeading | pubmed-meshheading:2023915-... | lld:pubmed |
| pubmed-article:2023915 | pubmed:meshHeading | pubmed-meshheading:2023915-... | lld:pubmed |
| pubmed-article:2023915 | pubmed:meshHeading | pubmed-meshheading:2023915-... | lld:pubmed |
| pubmed-article:2023915 | pubmed:meshHeading | pubmed-meshheading:2023915-... | lld:pubmed |
| pubmed-article:2023915 | pubmed:meshHeading | pubmed-meshheading:2023915-... | lld:pubmed |
| pubmed-article:2023915 | pubmed:meshHeading | pubmed-meshheading:2023915-... | lld:pubmed |
| pubmed-article:2023915 | pubmed:meshHeading | pubmed-meshheading:2023915-... | lld:pubmed |
| pubmed-article:2023915 | pubmed:meshHeading | pubmed-meshheading:2023915-... | lld:pubmed |
| pubmed-article:2023915 | pubmed:meshHeading | pubmed-meshheading:2023915-... | lld:pubmed |
| pubmed-article:2023915 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2023915 | pubmed:articleTitle | Vitamin D deficiency causes a selective reduction in deposition of transforming growth factor beta in rat bone: possible mechanism for impaired osteoinduction. | lld:pubmed |
| pubmed-article:2023915 | pubmed:affiliation | Department of Periodontics, Loma Linda University, CA. | lld:pubmed |
