| pubmed-article:20233969 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20233969 | lifeskim:mentions | umls-concept:C0022688 | lld:lifeskim |
| pubmed-article:20233969 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:20233969 | lifeskim:mentions | umls-concept:C0018133 | lld:lifeskim |
| pubmed-article:20233969 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:20233969 | lifeskim:mentions | umls-concept:C0301630 | lld:lifeskim |
| pubmed-article:20233969 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:20233969 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:20233969 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:20233969 | pubmed:issue | 21 | lld:pubmed |
| pubmed-article:20233969 | pubmed:dateCreated | 2010-5-28 | lld:pubmed |
| pubmed-article:20233969 | pubmed:abstractText | Natural killer (NK) cells suppress graft-versus-host disease (GVHD) without causing GVHD themselves. Our previous studies demonstrated that allogeneic T cells and NK cells traffic similarly after allogeneic bone marrow transplantation (BMT). We therefore investigated the impact of donor NK cells on donor alloreactive T cells in GVHD induction. Animals receiving donor NK and T cells showed improved survival and decreased GVHD score compared with controls receiving donor T cells alone. Donor T cells exhibited less proliferation, lower CD25 expression, and decreased interferon-gamma (IFN-gamma) production in the presence of NK cells. In vivo, we observed perforin- and Fas ligand (FasL)-mediated reduction of donor T cell proliferation and increased T cell apoptosis in the presence of NK cells. Further, activated NK cells mediated direct lysis of reisolated GVHD-inducing T cells in vitro. The graft-versus-tumor (GVT) effect was retained in the presence of donor NK cells. We demonstrate a novel mechanism of NK cell-mediated GVHD reduction whereby donor NK cells inhibit and lyse autologous donor T cells activated during the initiation of GVHD. | lld:pubmed |
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| pubmed-article:20233969 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:20233969 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:20233969 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20233969 | pubmed:month | May | lld:pubmed |
| pubmed-article:20233969 | pubmed:issn | 1528-0020 | lld:pubmed |
| pubmed-article:20233969 | pubmed:author | pubmed-author:BakerJeanette... | lld:pubmed |
| pubmed-article:20233969 | pubmed:author | pubmed-author:NegrinRobert... | lld:pubmed |
| pubmed-article:20233969 | pubmed:author | pubmed-author:BeilhackAndre... | lld:pubmed |
| pubmed-article:20233969 | pubmed:author | pubmed-author:Leveson-Gower... | lld:pubmed |
| pubmed-article:20233969 | pubmed:author | pubmed-author:OlsonJanelle... | lld:pubmed |
| pubmed-article:20233969 | pubmed:author | pubmed-author:GillSaarS | lld:pubmed |
| pubmed-article:20233969 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20233969 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:20233969 | pubmed:volume | 115 | lld:pubmed |
| pubmed-article:20233969 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20233969 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20233969 | pubmed:pagination | 4293-301 | lld:pubmed |
| pubmed-article:20233969 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
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