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pubmed-article:20216409pubmed:abstractTextThe aims of the present study were to investigate the pharmacokinetic and pharmacodynamic (pk/pd) relationship of levodopa (l-dopa) in patients with advanced Parkinson disease (PD) and also to evaluate the effect of tolcapone on the pk/pd analysis of l-dopa in 1 patient with severe dyskinesias and fluctuations.lld:pubmed
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pubmed-article:20216409pubmed:articleTitlePharmacokinetic-pharmacodynamic modeling of levodopa in patients with advanced Parkinson disease.lld:pubmed
pubmed-article:20216409pubmed:affiliationDepartments of Pharmacokinetics and Therapeutic Drug Monitoring, Pomeranian Medical University, Szczecin, Poland.lld:pubmed
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