| pubmed-article:20207753 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20207753 | lifeskim:mentions | umls-concept:C0162741 | lld:lifeskim |
| pubmed-article:20207753 | lifeskim:mentions | umls-concept:C0038435 | lld:lifeskim |
| pubmed-article:20207753 | lifeskim:mentions | umls-concept:C0149784 | lld:lifeskim |
| pubmed-article:20207753 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:20207753 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:20207753 | lifeskim:mentions | umls-concept:C0040649 | lld:lifeskim |
| pubmed-article:20207753 | lifeskim:mentions | umls-concept:C0439855 | lld:lifeskim |
| pubmed-article:20207753 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20207753 | lifeskim:mentions | umls-concept:C1706853 | lld:lifeskim |
| pubmed-article:20207753 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:20207753 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20207753 | pubmed:dateCreated | 2010-4-26 | lld:pubmed |
| pubmed-article:20207753 | pubmed:abstractText | Stress agents known to elicit the unfolded protein response in Arabidopsis thaliana upregulate the expression of a constellation of genes dependent on the membrane-associated basic domain/leucine zipper (bZIP) transcription factor, bZIP28. Among the stress-activated genes, a consensus promoter sequence corresponding to the endoplasmic reticulum (ER) stress-responsive element I (ERSE-I), CCAAT-N10-CACG, was identified. Disruption of either the CCAAT or CACG subelement in ERSE-I resulted in reduction of the transcriptional response to ER stress. bZIP28 forms homo- and heterodimers with other bZIP TF family members (in subgroup D) and interacts with CCAAT box binding factors, heterotrimeric factors composed of NF-Y subunits. Arabidopsis encodes 36 NF-Y subunits, and it was found that subunits NF-YB3 and -YC2 interact with bZIP28 and NF-YA4, respectively, in a yeast three-hybrid system. A transcriptional complex containing bZIP28 and the above-mentioned three NF-Y subunits was assembled in vitro on DNA containing ERSE-I. bZIP28, on its own, binds to the CACG subelement in ERSE-I to form a smaller complex I, and in combination with the NF-Y subunits above, bZIP28 assembles into a larger transcriptional complex (complex II). bZIP28 was shown to interact with NF-Y subunits in vivo in bimolecular fluorescence complementation analyses and in coimmunoprecipitation assays. Treatment of seedlings with ER stress agents led to the upregulation of NF-YC2 and the relocation of NF-YB3 from the cytoplasm to the nucleus. Thus, in response to ER stress, bZIP28 is mobilized by proteolysis and recruits NF-Y subunits to form a transcriptional complex that upregulates the expression of ER stress-induced genes. | lld:pubmed |
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| pubmed-article:20207753 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20207753 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20207753 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20207753 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20207753 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20207753 | pubmed:issn | 1532-298X | lld:pubmed |
| pubmed-article:20207753 | pubmed:author | pubmed-author:LiuJian-Xiang... | lld:pubmed |
| pubmed-article:20207753 | pubmed:author | pubmed-author:HowellStephen... | lld:pubmed |
| pubmed-article:20207753 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20207753 | pubmed:volume | 22 | lld:pubmed |
| pubmed-article:20207753 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20207753 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20207753 | pubmed:pagination | 782-96 | lld:pubmed |
| pubmed-article:20207753 | pubmed:dateRevised | 2011-7-25 | lld:pubmed |
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