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SubjectPredicateObjectContext
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pubmed-article:20207610pubmed:issue11lld:pubmed
pubmed-article:20207610pubmed:dateCreated2010-11-15lld:pubmed
pubmed-article:20207610pubmed:abstractTextThe use of corticosteroids for treatment of Duchenne and Becker muscular dystrophy in clinical practice from 1991 through 2005 was reviewed in a large population-based cohort (MD STARnet) of boys in 4 regional sites and 6 clinics of the United States. Corticosteroid use increased from 20% (11 of 56 individuals) in 1991 to 44% (93 of 218 individuals) in 2005. Average use varied by site and ranged from 15% to 49%. The median age of corticosteroid initiation was 6.9 years (range, 3.7-17.4 years). Dosage and growth information was available for 102 participants and showed a median dose as 0.729 mg/kg for prednisone and 0.831 mg/kg for deflazacort. T. The most common reasons that corticosteroids were discontinued included weight gain, behavioral side effects, and loss of ambulation, resulting in full-time wheelchair use. Substantial variations in clinical practice were identified among study sites.lld:pubmed
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pubmed-article:20207610pubmed:monthNovlld:pubmed
pubmed-article:20207610pubmed:issn1708-8283lld:pubmed
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pubmed-article:20207610pubmed:authorpubmed-author:PandyaShreeSlld:pubmed
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pubmed-article:20207610pubmed:volume25lld:pubmed
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pubmed-article:20207610pubmed:articleTitleUse of corticosteroids in a population-based cohort of boys with duchenne and becker muscular dystrophy.lld:pubmed
pubmed-article:20207610pubmed:affiliationDepartment of Physical Medicine & Rehabilitation, University of Colorado School of Medicine and The Children's Hospital, Denver, CO 80045, USA. matthews.dennis@tchden.orglld:pubmed
pubmed-article:20207610pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20207610pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed