| pubmed-article:20195239 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20195239 | lifeskim:mentions | umls-concept:C0374711 | lld:lifeskim |
| pubmed-article:20195239 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:20195239 | lifeskim:mentions | umls-concept:C0043240 | lld:lifeskim |
| pubmed-article:20195239 | lifeskim:mentions | umls-concept:C0151650 | lld:lifeskim |
| pubmed-article:20195239 | lifeskim:mentions | umls-concept:C1823140 | lld:lifeskim |
| pubmed-article:20195239 | lifeskim:mentions | umls-concept:C1705181 | lld:lifeskim |
| pubmed-article:20195239 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:20195239 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:20195239 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20195239 | pubmed:dateCreated | 2010-5-28 | lld:pubmed |
| pubmed-article:20195239 | pubmed:abstractText | Interaction between epithelial cells and mesenchymal cells is essential in normal organ morphogenesis and in tissue repair after injury. Epimorphin, a mesenchymal protein that regulates epithelial morphogenesis through epithelial-mesenchymal interactions, has recently attracted attention as an important modulator of tissue repair. In this study we analyzed the role of epimorphin in renal fibrosis. We first found a progressive increase in epimorphin expression corresponding to the progression of renal fibrosis in mice with unilateral ureteral obstruction (UUO). To determine whether this expression has a role in the repair or progression of renal fibrosis, we analyzed a model of renal fibrosis repair, the UUO-release (UUO-R) model. Epimorphin expression was increased at 3 and 7 days after the UUO-R rather than on the day of release, but was decreased at 21 days after the release. Inhibition of endogenous epimorphin with anti-epimorphin antibody (MC-1) significantly delayed the repair of fibrosis. When compared with normal-IgG-injected mice, MC-1-injected mice showed significantly decreased renal matrix metalloproteinase (MMP)-2 and MMP-9 expressions by western blotting and increased expression of TGF-beta and collagen-I mRNA by real-time RT-PCR. Recombinant epimorphin induced prominent increases in MMP-2 and MMP-9 activities in the culture media of renal interstitial fibroblasts in vitro. These findings indicate that epimorphin has a pivotal role in the repair of renal fibrosis by modulating both extracellular matrix (ECM) degradation and its production. | lld:pubmed |
| pubmed-article:20195239 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20195239 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20195239 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20195239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20195239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20195239 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20195239 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20195239 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20195239 | pubmed:issn | 1530-0307 | lld:pubmed |
| pubmed-article:20195239 | pubmed:author | pubmed-author:SakuraiYutaka... | lld:pubmed |
| pubmed-article:20195239 | pubmed:author | pubmed-author:MiuraSoichiro... | lld:pubmed |
| pubmed-article:20195239 | pubmed:author | pubmed-author:YamakamiKazuo... | lld:pubmed |
| pubmed-article:20195239 | pubmed:author | pubmed-author:OdaTakashiT | lld:pubmed |
| pubmed-article:20195239 | pubmed:author | pubmed-author:KumagaiHirooH | lld:pubmed |
| pubmed-article:20195239 | pubmed:author | pubmed-author:YamadaMunehar... | lld:pubmed |
| pubmed-article:20195239 | pubmed:author | pubmed-author:SuzukiShigeno... | lld:pubmed |
| pubmed-article:20195239 | pubmed:author | pubmed-author:HiraiYoheiY | lld:pubmed |
| pubmed-article:20195239 | pubmed:author | pubmed-author:HyodoToshitak... | lld:pubmed |
| pubmed-article:20195239 | pubmed:author | pubmed-author:KushiyamaTake... | lld:pubmed |
| pubmed-article:20195239 | pubmed:author | pubmed-author:HigashiKeishi... | lld:pubmed |
| pubmed-article:20195239 | pubmed:author | pubmed-author:YamamotoKojir... | lld:pubmed |
| pubmed-article:20195239 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20195239 | pubmed:volume | 90 | lld:pubmed |
| pubmed-article:20195239 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20195239 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20195239 | pubmed:pagination | 867-80 | lld:pubmed |
| pubmed-article:20195239 | pubmed:meshHeading | pubmed-meshheading:20195239... | lld:pubmed |
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| pubmed-article:20195239 | pubmed:meshHeading | pubmed-meshheading:20195239... | lld:pubmed |
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| pubmed-article:20195239 | pubmed:meshHeading | pubmed-meshheading:20195239... | lld:pubmed |
| pubmed-article:20195239 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20195239 | pubmed:articleTitle | Involvement of epimorphin in the repair of experimental renal fibrosis in mice. | lld:pubmed |
| pubmed-article:20195239 | pubmed:affiliation | Division of Nephrology, Department of Internal Medicine, Saitama, Japan. | lld:pubmed |
| pubmed-article:20195239 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:13852 | entrezgene:pubmed | pubmed-article:20195239 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20195239 | lld:entrezgene |
