Linked Life Data

20190753

Source:http://linkedlifedata.com/resource/pubmed/id/20190753

Statements in which the resource exists.
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pubmed-article:20190753pubmed:abstractTextArthrogryposis, renal dysfunction and cholestasis syndrome (ARC) is a multisystem disorder associated with abnormalities in polarized liver and kidney cells. Mutations in VPS33B account for most cases of ARC. We identified mutations in VIPAR (also called C14ORF133) in individuals with ARC without VPS33B defects. We show that VIPAR forms a functional complex with VPS33B that interacts with RAB11A. Knockdown of vipar in zebrafish resulted in biliary excretion and E-cadherin defects similar to those in individuals with ARC. Vipar- and Vps33b-deficient mouse inner medullary collecting duct (mIMDC-3) cells expressed membrane proteins abnormally and had structural and functional tight junction defects. Abnormal Ceacam5 expression was due to mis-sorting toward lysosomal degradation, but reduced E-cadherin levels were associated with transcriptional downregulation. The VPS33B-VIPAR complex thus has diverse functions in the pathways regulating apical-basolateral polarity in the liver and kidney.lld:pubmed
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pubmed-article:20190753pubmed:articleTitleMutations in VIPAR cause an arthrogryposis, renal dysfunction and cholestasis syndrome phenotype with defects in epithelial polarization.lld:pubmed
pubmed-article:20190753pubmed:affiliationMedical and Molecular Genetics, School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, UK.lld:pubmed
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