| pubmed-article:20188247 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20188247 | lifeskim:mentions | umls-concept:C1519886 | lld:lifeskim |
| pubmed-article:20188247 | lifeskim:mentions | umls-concept:C0028953 | lld:lifeskim |
| pubmed-article:20188247 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:20188247 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:20188247 | lifeskim:mentions | umls-concept:C0056912 | lld:lifeskim |
| pubmed-article:20188247 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:20188247 | pubmed:dateCreated | 2010-3-1 | lld:pubmed |
| pubmed-article:20188247 | pubmed:abstractText | Synthetic oligodeoxynucleotides (ODN) containing unmethylated CpG motifs mimic the immunostimulatory activity of bacterial DNA. CpG ODN directly stimulate B cells and plasmacytoid dendritic cells (pDC), promote the production of Th1 and pro-inflammatory cytokines, and trigger the maturation/activation of professional antigen presenting cells. CpG ODN are finding use as vaccine adjuvants, where they increase the speed, magnitude and duration of vaccine-specific immune responses. For example, CpG ODN significantly prolong the protection induced by AVA (Anthrax Vaccine Adsorbed). Unexpectedly, a majority of animals immunized with CpG-adjuvanted AVA maintain resistance to anthrax infection even after their Ab titers decline to sub-protective levels. This survival is mediated by the de novo production of protective Abs by high affinity long-lived memory B cells. The immunostimulatory activity of CpG ODN was probed at the molecular level by microarray. Results show that a small group of 'inducers' rapidly up-regulated a large network genes following CpG treatment of mice. This stimulatory activity is quenched by 'suppressors' that down-regulate the expression of targeted genes, including most of the 'inducers'. These findings shed light on the mechanism underlying CpG-mediated immune activation and therapeutic activity. | lld:pubmed |
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| pubmed-article:20188247 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20188247 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20188247 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20188247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20188247 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20188247 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20188247 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20188247 | pubmed:issn | 1873-2518 | lld:pubmed |
| pubmed-article:20188247 | pubmed:author | pubmed-author:IkeuchiHideka... | lld:pubmed |
| pubmed-article:20188247 | pubmed:author | pubmed-author:KlinmanDennis... | lld:pubmed |
| pubmed-article:20188247 | pubmed:author | pubmed-author:ShirotaHideka... | lld:pubmed |
| pubmed-article:20188247 | pubmed:author | pubmed-author:KlaschikSvenS | lld:pubmed |
| pubmed-article:20188247 | pubmed:author | pubmed-author:TomaruKojiK | lld:pubmed |
| pubmed-article:20188247 | pubmed:author | pubmed-author:TrossDebraD | lld:pubmed |
| pubmed-article:20188247 | pubmed:copyrightInfo | Published by Elsevier Ltd. | lld:pubmed |
| pubmed-article:20188247 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20188247 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:20188247 | pubmed:volume | 28 | lld:pubmed |
| pubmed-article:20188247 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20188247 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20188247 | pubmed:pagination | 1919-23 | lld:pubmed |
| pubmed-article:20188247 | pubmed:dateRevised | 2011-7-25 | lld:pubmed |
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| pubmed-article:20188247 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20188247 | pubmed:articleTitle | Immunostimulatory CpG oligonucleotides: Effect on gene expression and utility as vaccine adjuvants. | lld:pubmed |
| pubmed-article:20188247 | pubmed:affiliation | Cancer and Inflammation Program, National Cancer Institute, Frederick, MD 21702, United States. klinmand@mail.nih.gov | lld:pubmed |
| pubmed-article:20188247 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20188247 | lld:pubmed |
