| pubmed-article:20179739 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20179739 | lifeskim:mentions | umls-concept:C0026769 | lld:lifeskim |
| pubmed-article:20179739 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:20179739 | lifeskim:mentions | umls-concept:C0021756 | lld:lifeskim |
| pubmed-article:20179739 | lifeskim:mentions | umls-concept:C1334114 | lld:lifeskim |
| pubmed-article:20179739 | lifeskim:mentions | umls-concept:C1334115 | lld:lifeskim |
| pubmed-article:20179739 | lifeskim:mentions | umls-concept:C1882417 | lld:lifeskim |
| pubmed-article:20179739 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:20179739 | pubmed:dateCreated | 2010-6-17 | lld:pubmed |
| pubmed-article:20179739 | pubmed:abstractText | Interleukin (IL)-2/IL-2R signalling promotes proliferation and survival of activated T cells and has an essential non-redundant role in the production of regulatory T cells. Associations with different autoimmune diseases of polymorphisms in a linkage disequilibrium block in which the IL2/IL21 genes map (4q27), and also in genes encoding the IL2RA and IL2RB subunits (located in 10p15 and 22q13, respectively), were identified through genome-wide studies. Polymorphisms in these three genes were studied in 430 multiple sclerosis (MS) patients and in 550 ethnically matched controls from Madrid (Spain). Replication and meta-analysis with results from an independent cohort of 771 MS patients and 759 controls from Andalucía (Spain) confirmed the association of polymorphisms in the IL2RA gene (P(Mantel-Haenszel,) odds ratio (OR)(M-H) (95% confidence interval, CI) for rs2104286: 0.0001, 0.75 (0.65-0.87); for rs11594656/rs35285258: 0.004, 1.19 (1.06-1.34); for rs41295061: 0.03, 0.77 (0.60-0.98)); showed a trend for association of the IL2/IL21 rs6822844 (P(M-H)=0.07, OR(M-H) (95% CI)=0.86 (0.73-1.01)), but did not corroborate the association for IL2RB. Regression analyses of the combined Spanish cohort revealed the independence of two IL2RA association signals: rs2104286 and rs11594656/rs35285258. The relevant role of the IL2RA gene on MS susceptibility adds support to its common effect on autoimmune risk and the suggestive association of IL2/IL21 warrants further investigation. | lld:pubmed |
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| pubmed-article:20179739 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20179739 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179739 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20179739 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20179739 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:20179739 | pubmed:issn | 1476-5438 | lld:pubmed |
| pubmed-article:20179739 | pubmed:author | pubmed-author:FernándezOsca... | lld:pubmed |
| pubmed-article:20179739 | pubmed:author | pubmed-author:BartoloméManu... | lld:pubmed |
| pubmed-article:20179739 | pubmed:author | pubmed-author:Fernández-Arq... | lld:pubmed |
| pubmed-article:20179739 | pubmed:author | pubmed-author:de la... | lld:pubmed |
| pubmed-article:20179739 | pubmed:author | pubmed-author:NúñezConcepci... | lld:pubmed |
| pubmed-article:20179739 | pubmed:author | pubmed-author:UrcelayElenaE | lld:pubmed |
| pubmed-article:20179739 | pubmed:author | pubmed-author:ArroyoRafaelR | lld:pubmed |
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| pubmed-article:20179739 | pubmed:author | pubmed-author:MatesanzFuenc... | lld:pubmed |
| pubmed-article:20179739 | pubmed:author | pubmed-author:AlcinaAntonio... | lld:pubmed |
| pubmed-article:20179739 | pubmed:author | pubmed-author:CavanillasMar... | lld:pubmed |
| pubmed-article:20179739 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20179739 | pubmed:volume | 18 | lld:pubmed |
| pubmed-article:20179739 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20179739 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20179739 | pubmed:pagination | 794-9 | lld:pubmed |
| pubmed-article:20179739 | pubmed:dateRevised | 2011-8-1 | lld:pubmed |
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| pubmed-article:20179739 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20179739 | pubmed:articleTitle | Polymorphisms in the IL2, IL2RA and IL2RB genes in multiple sclerosis risk. | lld:pubmed |
| pubmed-article:20179739 | pubmed:affiliation | Immunology Department, Hospital Clínico San Carlos, Madrid, Spain. | lld:pubmed |
| pubmed-article:20179739 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20179739 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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