| pubmed-article:20179154 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20179154 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:20179154 | lifeskim:mentions | umls-concept:C2936411 | lld:lifeskim |
| pubmed-article:20179154 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:20179154 | lifeskim:mentions | umls-concept:C1423842 | lld:lifeskim |
| pubmed-article:20179154 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:20179154 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:20179154 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20179154 | pubmed:dateCreated | 2010-6-23 | lld:pubmed |
| pubmed-article:20179154 | pubmed:abstractText | Following activation through the TCR, CD4+ T cells can differentiate into three major subsets: Th1, Th2, and Th17 cells. IL-17-secreting Th17 cells play an important role in the pathogenesis of several autoimmune diseases and in immune responses to pathogens, but little is known about the regulation of apoptosis in Th17 cells. In this study, the sensitivity of in vitro-polarized Th1, Th2, and Th17 cells to Fas-mediated apoptosis was compared directly by different methods. The order of sensitivity of T cell subsets to Fas-mediated apoptosis is: Th1 > Th17 > Th2. The greater sensitivity of Th17 cells to Fas-mediated apoptosis compared with Th2 cells correlated with their higher expression of FasL and comparable expression of the antiapoptotic molecule FLIP. The decreased sensitivity of Th17 compared with Th1 cells correlated with the higher expression of FLIP by Th17 cells. Transgenic overexpression of FLIP in T cells protected all three subsets from Fas-mediated apoptosis. These findings provide new knowledge for understanding how survival of different subsets of T cells is regulated. | lld:pubmed |
| pubmed-article:20179154 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20179154 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20179154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20179154 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20179154 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20179154 | pubmed:issn | 1938-3673 | lld:pubmed |
| pubmed-article:20179154 | pubmed:author | pubmed-author:YuShiguangS | lld:pubmed |
| pubmed-article:20179154 | pubmed:author | pubmed-author:Braley-Mullen... | lld:pubmed |
| pubmed-article:20179154 | pubmed:author | pubmed-author:EllisJason... | lld:pubmed |
| pubmed-article:20179154 | pubmed:author | pubmed-author:SharavTumenja... | lld:pubmed |
| pubmed-article:20179154 | pubmed:author | pubmed-author:FangYujiangY | lld:pubmed |
| pubmed-article:20179154 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20179154 | pubmed:volume | 87 | lld:pubmed |
| pubmed-article:20179154 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20179154 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20179154 | pubmed:pagination | 1019-28 | lld:pubmed |
| pubmed-article:20179154 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
| pubmed-article:20179154 | pubmed:meshHeading | pubmed-meshheading:20179154... | lld:pubmed |
