| pubmed-article:20174559 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20174559 | lifeskim:mentions | umls-concept:C0035690 | lld:lifeskim |
| pubmed-article:20174559 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:20174559 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:20174559 | lifeskim:mentions | umls-concept:C1424774 | lld:lifeskim |
| pubmed-article:20174559 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:20174559 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:20174559 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20174559 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:20174559 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20174559 | pubmed:dateCreated | 2010-2-22 | lld:pubmed |
| pubmed-article:20174559 | pubmed:abstractText | The innate immune response provides a critical defense against microbial infections, including viruses. These are recognised by pattern recognition receptors including Toll-like receptors (TLRs) and RIG-I like helicases (RLHs). Detection of virus triggers signalling cascades that induce transcription of type I interferons including IFNbeta, which are pivotal for the initiation of an anti-viral state. Despite the essential role of IFNbeta in the anti-viral response, there is an incomplete understanding of the negative regulation of IFNbeta induction. Here we provide evidence that expression of the Nemo-related protein, optineurin (NRP/FIP2), has a role in the inhibition of virus-triggered IFNbeta induction. Over-expression of optineurin inhibited Sendai-virus (SeV) and dsRNA triggered induction of IFNbeta, whereas depletion of optineurin with siRNA promoted virus-induced IFNbeta production and decreased RNA virus replication. Immunoprecipitation and immunofluorescence studies identified optineurin in a protein complex containing the antiviral protein kinase TBK1 and the ubiquitin ligase TRAF3. Furthermore, mutagenesis studies determined that binding of ubiquitin was essential for both the correct sub-cellular localisation and the inhibitory function of optineurin. This work identifies optineurin as a critical regulator of antiviral signalling and potential target for future antiviral therapy. | lld:pubmed |
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| pubmed-article:20174559 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20174559 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20174559 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20174559 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20174559 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20174559 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20174559 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20174559 | pubmed:issn | 1553-7374 | lld:pubmed |
| pubmed-article:20174559 | pubmed:author | pubmed-author:HarrisMarkM | lld:pubmed |
| pubmed-article:20174559 | pubmed:author | pubmed-author:ElliottRichar... | lld:pubmed |
| pubmed-article:20174559 | pubmed:author | pubmed-author:MacdonaldAndr... | lld:pubmed |
| pubmed-article:20174559 | pubmed:author | pubmed-author:KohlAlainA | lld:pubmed |
| pubmed-article:20174559 | pubmed:author | pubmed-author:MankouriJamel... | lld:pubmed |
| pubmed-article:20174559 | pubmed:author | pubmed-author:RichardsKathr... | lld:pubmed |
| pubmed-article:20174559 | pubmed:author | pubmed-author:FragkoudisRen... | lld:pubmed |
| pubmed-article:20174559 | pubmed:author | pubmed-author:WetherillLaur... | lld:pubmed |
| pubmed-article:20174559 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20174559 | pubmed:volume | 6 | lld:pubmed |
| pubmed-article:20174559 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20174559 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20174559 | pubmed:pagination | e1000778 | lld:pubmed |
| pubmed-article:20174559 | pubmed:dateRevised | 2010-9-30 | lld:pubmed |
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| pubmed-article:20174559 | pubmed:meshHeading | pubmed-meshheading:20174559... | lld:pubmed |
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| pubmed-article:20174559 | pubmed:meshHeading | pubmed-meshheading:20174559... | lld:pubmed |
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| pubmed-article:20174559 | pubmed:meshHeading | pubmed-meshheading:20174559... | lld:pubmed |
