| pubmed-article:20173027 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20173027 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:20173027 | lifeskim:mentions | umls-concept:C0017355 | lld:lifeskim |
| pubmed-article:20173027 | lifeskim:mentions | umls-concept:C0014239 | lld:lifeskim |
| pubmed-article:20173027 | lifeskim:mentions | umls-concept:C0206430 | lld:lifeskim |
| pubmed-article:20173027 | lifeskim:mentions | umls-concept:C0002570 | lld:lifeskim |
| pubmed-article:20173027 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:20173027 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:20173027 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:20173027 | lifeskim:mentions | umls-concept:C0486616 | lld:lifeskim |
| pubmed-article:20173027 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:20173027 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20173027 | pubmed:dateCreated | 2010-3-4 | lld:pubmed |
| pubmed-article:20173027 | pubmed:abstractText | The MHC class I (MHC-I) molecules ferry a cargo of peptides to the cell surface as potential ligands for CD8(+) cytotoxic T cells. For nearly 20 years, the cargo has been described as a collection of short 8-9 mer peptides, whose length and sequences were believed to be primarily determined by the peptide-binding groove of MHC-I molecules. Yet the mechanisms for producing peptides of such optimal length and composition have remained unclear. In this study, using mass spectrometry, we determined the amino acid sequences of a large number of naturally processed peptides in mice lacking the endoplasmic reticulum aminopeptidase associated with Ag processing (ERAAP). We find that ERAAP-deficiency changed the oeuvre and caused a marked increase in the length of peptides normally presented by MHC-I. Furthermore, we observed similar changes in the length of viral peptides recognized by CD8(+) T cells in mouse CMV-infected ERAAP-deficient mice. In these mice, a distinct CD8(+) T cell population was elicited with specificity for an N-terminally extended epitope. Thus, the characteristic length, as well as the composition of MHC-I peptide cargo, is determined not only by the MHC-I peptide-binding groove but also by ERAAP proteolysis in the endoplasmic reticulum. | lld:pubmed |
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| pubmed-article:20173027 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20173027 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20173027 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:20173027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20173027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20173027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20173027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20173027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20173027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20173027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20173027 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20173027 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20173027 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20173027 | pubmed:issn | 1550-6606 | lld:pubmed |
| pubmed-article:20173027 | pubmed:author | pubmed-author:ShastriNilabh... | lld:pubmed |
| pubmed-article:20173027 | pubmed:author | pubmed-author:RauletDavid... | lld:pubmed |
| pubmed-article:20173027 | pubmed:author | pubmed-author:CrockettDavid... | lld:pubmed |
| pubmed-article:20173027 | pubmed:author | pubmed-author:BlanchardNico... | lld:pubmed |
| pubmed-article:20173027 | pubmed:author | pubmed-author:DelgadoJulio... | lld:pubmed |
| pubmed-article:20173027 | pubmed:author | pubmed-author:DelebecqueFré... | lld:pubmed |
| pubmed-article:20173027 | pubmed:author | pubmed-author:KanasekiTakay... | lld:pubmed |
| pubmed-article:20173027 | pubmed:author | pubmed-author:NagarajanNira... | lld:pubmed |
| pubmed-article:20173027 | pubmed:author | pubmed-author:EscobarHernan... | lld:pubmed |
| pubmed-article:20173027 | pubmed:author | pubmed-author:Reyes-VargasE... | lld:pubmed |
| pubmed-article:20173027 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20173027 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20173027 | pubmed:volume | 184 | lld:pubmed |
| pubmed-article:20173027 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20173027 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20173027 | pubmed:pagination | 3033-42 | lld:pubmed |
| pubmed-article:20173027 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
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