| pubmed-article:2017259 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2017259 | lifeskim:mentions | umls-concept:C0567416 | lld:lifeskim |
| pubmed-article:2017259 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:2017259 | lifeskim:mentions | umls-concept:C1880194 | lld:lifeskim |
| pubmed-article:2017259 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:2017259 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:2017259 | lifeskim:mentions | umls-concept:C1707489 | lld:lifeskim |
| pubmed-article:2017259 | pubmed:issue | 6319 | lld:pubmed |
| pubmed-article:2017259 | pubmed:dateCreated | 1991-5-23 | lld:pubmed |
| pubmed-article:2017259 | pubmed:abstractText | A principal goal of biotechnology is the assembly of novel biomaterials for analytical, industrial and therapeutic purposes. The advent of stable immobile nucleic acid branched junctions makes DNA a good candidate for building frameworks to which proteins or other functional molecules can be attached and thereby juxtaposed. The addition of single-stranded 'sticky' ends to branched DNA molecules converts them into macromolecular valence clusters that can be ligated together. The edges of these frameworks are double-helical DNA, and the vertices correspond to the branch points of junctions. Here, we report the construction from DNA of a covalently closed cube-like molecular complex containing twelve equal-length double-helical edges arranged about eight vertices. Each of the six 'faces' of the object is a single-stranded cyclic molecule, doubly catenated to four neighbouring strands, and each vertex is connected by an edge to three others. Each edge contains a unique restriction site for analytical purposes. This is the first construction of a closed polyhedral object from DNA. | lld:pubmed |
| pubmed-article:2017259 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2017259 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2017259 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2017259 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2017259 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2017259 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2017259 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:2017259 | pubmed:author | pubmed-author:ChenJ HJH | lld:pubmed |
| pubmed-article:2017259 | pubmed:author | pubmed-author:SeemanN CNC | lld:pubmed |
| pubmed-article:2017259 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2017259 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:2017259 | pubmed:volume | 350 | lld:pubmed |
| pubmed-article:2017259 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2017259 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2017259 | pubmed:pagination | 631-3 | lld:pubmed |
| pubmed-article:2017259 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:2017259 | pubmed:meshHeading | pubmed-meshheading:2017259-... | lld:pubmed |
| pubmed-article:2017259 | pubmed:meshHeading | pubmed-meshheading:2017259-... | lld:pubmed |
| pubmed-article:2017259 | pubmed:meshHeading | pubmed-meshheading:2017259-... | lld:pubmed |
| pubmed-article:2017259 | pubmed:meshHeading | pubmed-meshheading:2017259-... | lld:pubmed |
| pubmed-article:2017259 | pubmed:meshHeading | pubmed-meshheading:2017259-... | lld:pubmed |
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| pubmed-article:2017259 | pubmed:meshHeading | pubmed-meshheading:2017259-... | lld:pubmed |
| pubmed-article:2017259 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2017259 | pubmed:articleTitle | Synthesis from DNA of a molecule with the connectivity of a cube. | lld:pubmed |
| pubmed-article:2017259 | pubmed:affiliation | Department of Chemistry, New York University, New York 10003. | lld:pubmed |
| pubmed-article:2017259 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2017259 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:2017259 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| pubmed-article:2017259 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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