| pubmed-article:20170959 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20170959 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:20170959 | lifeskim:mentions | umls-concept:C0085243 | lld:lifeskim |
| pubmed-article:20170959 | lifeskim:mentions | umls-concept:C0085112 | lld:lifeskim |
| pubmed-article:20170959 | lifeskim:mentions | umls-concept:C0229664 | lld:lifeskim |
| pubmed-article:20170959 | lifeskim:mentions | umls-concept:C0027022 | lld:lifeskim |
| pubmed-article:20170959 | lifeskim:mentions | umls-concept:C0009013 | lld:lifeskim |
| pubmed-article:20170959 | lifeskim:mentions | umls-concept:C0301944 | lld:lifeskim |
| pubmed-article:20170959 | lifeskim:mentions | umls-concept:C0882849 | lld:lifeskim |
| pubmed-article:20170959 | lifeskim:mentions | umls-concept:C0751781 | lld:lifeskim |
| pubmed-article:20170959 | lifeskim:mentions | umls-concept:C0443199 | lld:lifeskim |
| pubmed-article:20170959 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:20170959 | pubmed:dateCreated | 2010-8-27 | lld:pubmed |
| pubmed-article:20170959 | pubmed:abstractText | We evaluated the NOD/SCID engraftment of CD34(+) cells from polycythemia vera (PV) and secondary polycythemia patients (SP) and the JAK2V617F clone before and after transplantation. Peripheral blood CD34(+) cells were transplanted intra-femorally. In the injected BM, successful engraftment (>0.1%) occurred in 8/26 mice transplanted with CD34+ cells from 5/13 PV patients (median: 4.26%, range: 0.3-5.56%), in contrast to 0/14 mice from 9 SP patients (P=0.017). The engrafting PV cells were of multi-lineage. JAK2V617F/total JAK2 ratios decreased after transplantation (initial: 65.9% versus 6-week: 13.0%, P=0.001). Essential thrombocythemia (ET) BM cells also exhibited a similar decrease in JAK2V617F clone. The results suggested that events in addition to JAK2V617F are involved in the pathogenesis of PV and ET. | lld:pubmed |
| pubmed-article:20170959 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20170959 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20170959 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20170959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20170959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20170959 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20170959 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20170959 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:20170959 | pubmed:issn | 1873-5835 | lld:pubmed |
| pubmed-article:20170959 | pubmed:author | pubmed-author:KwongYok-LamY... | lld:pubmed |
| pubmed-article:20170959 | pubmed:author | pubmed-author:LiangRaymondR | lld:pubmed |
| pubmed-article:20170959 | pubmed:author | pubmed-author:LeungAnskar... | lld:pubmed |
| pubmed-article:20170959 | pubmed:author | pubmed-author:CheungAlice... | lld:pubmed |
| pubmed-article:20170959 | pubmed:author | pubmed-author:FungTsz-KanTK | lld:pubmed |
| pubmed-article:20170959 | pubmed:copyrightInfo | Copyright (c) 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20170959 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20170959 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:20170959 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20170959 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20170959 | pubmed:pagination | 1390-4 | lld:pubmed |
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| pubmed-article:20170959 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20170959 | pubmed:articleTitle | Differential NOD/SCID mouse engraftment of peripheral blood CD34+ cells and JAK2V617F clones from patients with myeloproliferative neoplasms. | lld:pubmed |
| pubmed-article:20170959 | pubmed:affiliation | Department of Medicine, Queen Mary Hospital, The University of Hong Kong, Pokfulam Road, Hong Kong, Hong Kong, China. | lld:pubmed |
| pubmed-article:20170959 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20170959 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
