| pubmed-article:20153397 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20153397 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:20153397 | lifeskim:mentions | umls-concept:C0013018 | lld:lifeskim |
| pubmed-article:20153397 | lifeskim:mentions | umls-concept:C0022671 | lld:lifeskim |
| pubmed-article:20153397 | lifeskim:mentions | umls-concept:C0005953 | lld:lifeskim |
| pubmed-article:20153397 | lifeskim:mentions | umls-concept:C0205245 | lld:lifeskim |
| pubmed-article:20153397 | lifeskim:mentions | umls-concept:C1704410 | lld:lifeskim |
| pubmed-article:20153397 | lifeskim:mentions | umls-concept:C0439064 | lld:lifeskim |
| pubmed-article:20153397 | lifeskim:mentions | umls-concept:C1979963 | lld:lifeskim |
| pubmed-article:20153397 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:20153397 | lifeskim:mentions | umls-concept:C2003903 | lld:lifeskim |
| pubmed-article:20153397 | lifeskim:mentions | umls-concept:C1510438 | lld:lifeskim |
| pubmed-article:20153397 | lifeskim:mentions | umls-concept:C2348480 | lld:lifeskim |
| pubmed-article:20153397 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20153397 | pubmed:dateCreated | 2010-5-20 | lld:pubmed |
| pubmed-article:20153397 | pubmed:abstractText | Ex vivo identification of donor-specific unresponsiveness in organ transplant recipients is important for immunosuppression (IS) minimization. We tested three groups of stable living, related-donor kidney transplant patients up to 11 years postoperatively, i.e., 20 haploidenticals with donor bone marrow cell (DBMC) infusions, eight noninfused haploidentical controls (haplo controls), and 11 HLA-identical controls (HLA-id), using multiple ex vivo immune assays. We observed that no patients developed donor-specific antibodies. The majority showed donor-specific CTL unresponsiveness from year 1 onward. Thirteen of 20 DBMC recipients became specifically donor MLR nonreactive. Depletion of donor cells in DBMC recipients still MLR reactive increased donor-specific reactivity by 75% +/- 36% (p = 0.04). Adding them back in low concentration caused antigen specific inhibition. The frequencies of ELISPOT granzyme-B and interferon-gamma-producing cells somewhat paralleled the CTL and MLR responses. In the trans vivo DTH, 14 of 19 DBMC recipients demonstrated donor-specific unresponsiveness and 16 of 19 showed "linked suppression," vs none of eight and one of eight haplo controls and vs six of 10 and one of 10 HLA-ids, respectively. Most importantly, when all six assays were performed simultaneously, 10 of 18 DBMC, five of 10 HLA-ids, and no haplo controls were specifically donor unresponsive long term. We propose that a cluster analysis combining these assays will reveal tolerant recipients in whom IS minimization may safely be tested. This appears to have occurred in many DBMC-infused recipients. | lld:pubmed |
| pubmed-article:20153397 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20153397 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20153397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153397 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20153397 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20153397 | pubmed:issn | 1879-1166 | lld:pubmed |
| pubmed-article:20153397 | pubmed:author | pubmed-author:RicordiCamill... | lld:pubmed |
| pubmed-article:20153397 | pubmed:author | pubmed-author:BurkeGeorge... | lld:pubmed |
| pubmed-article:20153397 | pubmed:author | pubmed-author:WangEdwardE | lld:pubmed |
| pubmed-article:20153397 | pubmed:author | pubmed-author:MillerJoshuaJ | lld:pubmed |
| pubmed-article:20153397 | pubmed:author | pubmed-author:CiancioGaetan... | lld:pubmed |
| pubmed-article:20153397 | pubmed:author | pubmed-author:RosenAnneA | lld:pubmed |
| pubmed-article:20153397 | pubmed:author | pubmed-author:EsquenaziViol... | lld:pubmed |
| pubmed-article:20153397 | pubmed:author | pubmed-author:FullerLaphall... | lld:pubmed |
| pubmed-article:20153397 | pubmed:author | pubmed-author:BlombergBonni... | lld:pubmed |
| pubmed-article:20153397 | pubmed:author | pubmed-author:MathewJames... | lld:pubmed |
| pubmed-article:20153397 | pubmed:author | pubmed-author:Garcia-Morale... | lld:pubmed |
| pubmed-article:20153397 | pubmed:author | pubmed-author:GomezCarmen... | lld:pubmed |
| pubmed-article:20153397 | pubmed:copyrightInfo | Copyright 2010 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20153397 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20153397 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:20153397 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20153397 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20153397 | pubmed:pagination | 566-76 | lld:pubmed |
| pubmed-article:20153397 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
| pubmed-article:20153397 | pubmed:meshHeading | pubmed-meshheading:20153397... | lld:pubmed |
| pubmed-article:20153397 | pubmed:meshHeading | pubmed-meshheading:20153397... | lld:pubmed |
| pubmed-article:20153397 | pubmed:meshHeading | pubmed-meshheading:20153397... | lld:pubmed |
| pubmed-article:20153397 | pubmed:meshHeading | pubmed-meshheading:20153397... | lld:pubmed |
| pubmed-article:20153397 | pubmed:meshHeading | pubmed-meshheading:20153397... | lld:pubmed |
| pubmed-article:20153397 | pubmed:meshHeading | pubmed-meshheading:20153397... | lld:pubmed |
| pubmed-article:20153397 | pubmed:meshHeading | pubmed-meshheading:20153397... | lld:pubmed |
| pubmed-article:20153397 | pubmed:meshHeading | pubmed-meshheading:20153397... | lld:pubmed |
| pubmed-article:20153397 | pubmed:meshHeading | pubmed-meshheading:20153397... | lld:pubmed |
| pubmed-article:20153397 | pubmed:meshHeading | pubmed-meshheading:20153397... | lld:pubmed |
| pubmed-article:20153397 | pubmed:meshHeading | pubmed-meshheading:20153397... | lld:pubmed |
| pubmed-article:20153397 | pubmed:meshHeading | pubmed-meshheading:20153397... | lld:pubmed |
| pubmed-article:20153397 | pubmed:meshHeading | pubmed-meshheading:20153397... | lld:pubmed |
| pubmed-article:20153397 | pubmed:meshHeading | pubmed-meshheading:20153397... | lld:pubmed |
| pubmed-article:20153397 | pubmed:meshHeading | pubmed-meshheading:20153397... | lld:pubmed |
| pubmed-article:20153397 | pubmed:meshHeading | pubmed-meshheading:20153397... | lld:pubmed |
