| pubmed-article:20153207 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20153207 | lifeskim:mentions | umls-concept:C0007004 | lld:lifeskim |
| pubmed-article:20153207 | lifeskim:mentions | umls-concept:C0035419 | lld:lifeskim |
| pubmed-article:20153207 | lifeskim:mentions | umls-concept:C0039411 | lld:lifeskim |
| pubmed-article:20153207 | lifeskim:mentions | umls-concept:C1704241 | lld:lifeskim |
| pubmed-article:20153207 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20153207 | pubmed:dateCreated | 2010-3-15 | lld:pubmed |
| pubmed-article:20153207 | pubmed:abstractText | Three carbohydrate conjugated dipicolylamine chelators, 2-bis(2-pyridinylmethyl)amino)ethyl 1-deoxy-1-thio-beta-D-glucopyranoside (L(1)), 2-bis(2-pyridinylmethyl)amino)ethyl-beta-D-glucopyranoside (L(2)), and 2-bis(2-pyridinylmethyl)amino)carboxamide-N-(2-amino-2-deoxy-D-glucopyranose) (L(3)) were complexed to the [M(CO)(3)](+) core (M=Tc, Re) and the properties of the resulting complexes were investigated. Synthesis and characterization of the chelator 2-bis(2-pyridinylmethyl)amino)ethyl 1-deoxy-1-thio-beta-D-glucopyranoside (L(1)) and the corresponding Re complex are reported. All chelators were radiolabeled in high yield with [(99m)Tc(CO)(3)(H(2)O)(3)](+) (>98%) and [(186)Re(CO)(3)(H(2)O)(3)](+) (>80%). The chelators and Re-complexes were determined to not be substrates for the glucose metabolism enzyme hexokinase. However, the biodistribution of each of the (99m)Tc complexes demonstrated fast clearance from most background tissue, including >75% clearance of the activity in the kidneys and the liver within 2h post-injection. | lld:pubmed |
| pubmed-article:20153207 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20153207 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153207 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20153207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153207 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20153207 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20153207 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20153207 | pubmed:issn | 1872-9800 | lld:pubmed |
| pubmed-article:20153207 | pubmed:author | pubmed-author:StorrTimT | lld:pubmed |
| pubmed-article:20153207 | pubmed:author | pubmed-author:OrvigChrisC | lld:pubmed |
| pubmed-article:20153207 | pubmed:author | pubmed-author:ChammasRogerR | lld:pubmed |
| pubmed-article:20153207 | pubmed:author | pubmed-author:MikataYujiY | lld:pubmed |
| pubmed-article:20153207 | pubmed:author | pubmed-author:AdamMichael... | lld:pubmed |
| pubmed-article:20153207 | pubmed:author | pubmed-author:YanoShigenobu... | lld:pubmed |
| pubmed-article:20153207 | pubmed:author | pubmed-author:SugaiYukoY | lld:pubmed |
| pubmed-article:20153207 | pubmed:author | pubmed-author:FerreiraCara... | lld:pubmed |
| pubmed-article:20153207 | pubmed:author | pubmed-author:OtakeAndréia... | lld:pubmed |
| pubmed-article:20153207 | pubmed:author | pubmed-author:MarquesFabio... | lld:pubmed |
| pubmed-article:20153207 | pubmed:author | pubmed-author:OkamotoMiriam... | lld:pubmed |
| pubmed-article:20153207 | pubmed:author | pubmed-author:BowenMerynM | lld:pubmed |
| pubmed-article:20153207 | pubmed:copyrightInfo | Copyright 2010 Elsevier Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20153207 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20153207 | pubmed:volume | 68 | lld:pubmed |
| pubmed-article:20153207 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20153207 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20153207 | pubmed:pagination | 1087-93 | lld:pubmed |
| pubmed-article:20153207 | pubmed:meshHeading | pubmed-meshheading:20153207... | lld:pubmed |
| pubmed-article:20153207 | pubmed:meshHeading | pubmed-meshheading:20153207... | lld:pubmed |
| pubmed-article:20153207 | pubmed:meshHeading | pubmed-meshheading:20153207... | lld:pubmed |
| pubmed-article:20153207 | pubmed:meshHeading | pubmed-meshheading:20153207... | lld:pubmed |
| pubmed-article:20153207 | pubmed:meshHeading | pubmed-meshheading:20153207... | lld:pubmed |
| pubmed-article:20153207 | pubmed:meshHeading | pubmed-meshheading:20153207... | lld:pubmed |
| pubmed-article:20153207 | pubmed:meshHeading | pubmed-meshheading:20153207... | lld:pubmed |
| pubmed-article:20153207 | pubmed:meshHeading | pubmed-meshheading:20153207... | lld:pubmed |
| pubmed-article:20153207 | pubmed:meshHeading | pubmed-meshheading:20153207... | lld:pubmed |
| pubmed-article:20153207 | pubmed:meshHeading | pubmed-meshheading:20153207... | lld:pubmed |
| pubmed-article:20153207 | pubmed:meshHeading | pubmed-meshheading:20153207... | lld:pubmed |
| pubmed-article:20153207 | pubmed:meshHeading | pubmed-meshheading:20153207... | lld:pubmed |
| pubmed-article:20153207 | pubmed:meshHeading | pubmed-meshheading:20153207... | lld:pubmed |
| pubmed-article:20153207 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20153207 | pubmed:articleTitle | Cationic technetium and rhenium complexes with pendant carbohydrates. | lld:pubmed |
| pubmed-article:20153207 | pubmed:affiliation | Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC, Canada. | lld:pubmed |
| pubmed-article:20153207 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20153207 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
