| pubmed-article:2014801 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2014801 | lifeskim:mentions | umls-concept:C0025286 | lld:lifeskim |
| pubmed-article:2014801 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:2014801 | lifeskim:mentions | umls-concept:C0475264 | lld:lifeskim |
| pubmed-article:2014801 | lifeskim:mentions | umls-concept:C1552961 | lld:lifeskim |
| pubmed-article:2014801 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:2014801 | pubmed:dateCreated | 1991-5-15 | lld:pubmed |
| pubmed-article:2014801 | pubmed:abstractText | Cytogenetic analysis of meningioma cells from one particular patient (MN32) displayed the stem-line karyo-type 45, XY, -1, 4p+, 22q-, 22q+, which thus had rearrangements of both chromosomes 22. The 22q+ marker appeared as a dicentric: 22 pter----q11::1p11----qter. The reciprocal product of this translocation has presumably been lost because it lacked a centromere. The 22q- chromosome also appeared to have lost sequences distal to band q11. We assumed that this marker could have been the result of a reciprocal translocation between chromosomes 4 and 22. To investigate the 4p+ and 22q- chromosomes in more detail, human-hamster somatic cell hybrids were constructed that segregated the 22q- and 4p+ chromosomes. Southern blot analysis with DNA from these hybrids showed that sequences from 22q were indeed translocated to 4p+ and that reciprocally sequences from 4p were translocated to 22q-, demonstrating a balanced t(4;22)(p16;q11). On the basis of these results we presume that in this tumor a tumor-suppressor gene is deleted in the case of the 22q+ marker and that the t(4;22) disrupts the second allele of this gene. The latter translocation was mapped between D22S1 and D22S15, a distance of 1 cM on the linkage map of this chromosome. The area in which we have located the translocation is within the region where the gene predisposing to neurofibromatosis 2 has been mapped. | lld:pubmed |
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| pubmed-article:2014801 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2014801 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2014801 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2014801 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2014801 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2014801 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2014801 | pubmed:issn | 0002-9297 | lld:pubmed |
| pubmed-article:2014801 | pubmed:author | pubmed-author:BootsmaDD | lld:pubmed |
| pubmed-article:2014801 | pubmed:author | pubmed-author:HagemeijerAA | lld:pubmed |
| pubmed-article:2014801 | pubmed:author | pubmed-author:AvezaatC JCJ | lld:pubmed |
| pubmed-article:2014801 | pubmed:author | pubmed-author:ZwarthoffE... | lld:pubmed |
| pubmed-article:2014801 | pubmed:author | pubmed-author:KoperJ WJW | lld:pubmed |
| pubmed-article:2014801 | pubmed:author | pubmed-author:Lekanne... | lld:pubmed |
| pubmed-article:2014801 | pubmed:author | pubmed-author:van BiezenN... | lld:pubmed |
| pubmed-article:2014801 | pubmed:author | pubmed-author:GroenN ANA | lld:pubmed |
| pubmed-article:2014801 | pubmed:author | pubmed-author:van DrunenEE | lld:pubmed |
| pubmed-article:2014801 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2014801 | pubmed:volume | 48 | lld:pubmed |
| pubmed-article:2014801 | pubmed:geneSymbol | NF2 | lld:pubmed |
| pubmed-article:2014801 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2014801 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2014801 | pubmed:pagination | 783-90 | lld:pubmed |
| pubmed-article:2014801 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:2014801 | pubmed:meshHeading | pubmed-meshheading:2014801-... | lld:pubmed |
| pubmed-article:2014801 | pubmed:meshHeading | pubmed-meshheading:2014801-... | lld:pubmed |
| pubmed-article:2014801 | pubmed:meshHeading | pubmed-meshheading:2014801-... | lld:pubmed |
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| pubmed-article:2014801 | pubmed:meshHeading | pubmed-meshheading:2014801-... | lld:pubmed |
| pubmed-article:2014801 | pubmed:meshHeading | pubmed-meshheading:2014801-... | lld:pubmed |
| pubmed-article:2014801 | pubmed:meshHeading | pubmed-meshheading:2014801-... | lld:pubmed |
| pubmed-article:2014801 | pubmed:meshHeading | pubmed-meshheading:2014801-... | lld:pubmed |
| pubmed-article:2014801 | pubmed:meshHeading | pubmed-meshheading:2014801-... | lld:pubmed |
| pubmed-article:2014801 | pubmed:meshHeading | pubmed-meshheading:2014801-... | lld:pubmed |
| pubmed-article:2014801 | pubmed:meshHeading | pubmed-meshheading:2014801-... | lld:pubmed |
| pubmed-article:2014801 | pubmed:meshHeading | pubmed-meshheading:2014801-... | lld:pubmed |
| pubmed-article:2014801 | pubmed:meshHeading | pubmed-meshheading:2014801-... | lld:pubmed |
| pubmed-article:2014801 | pubmed:meshHeading | pubmed-meshheading:2014801-... | lld:pubmed |
| pubmed-article:2014801 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2014801 | pubmed:articleTitle | A t(4;22) in a meningioma points to the localization of a putative tumor-suppressor gene. | lld:pubmed |
| pubmed-article:2014801 | pubmed:affiliation | Departments of Pathology, Erasmus University, Rotterdam, The Netherlands. | lld:pubmed |
| pubmed-article:2014801 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:2014801 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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