| pubmed-article:20147626 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20147626 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:20147626 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:20147626 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:20147626 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:20147626 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:20147626 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:20147626 | pubmed:dateCreated | 2010-3-3 | lld:pubmed |
| pubmed-article:20147626 | pubmed:abstractText | Homeotic (Hox) genes encode transcription factors that confer segmental identity along the anteroposterior axis of the embryo. However the molecular mechanisms underlying Hox-mediated transcription and the differential requirements for specificity in the regulation of the vast number of Hox-target genes remain ill-defined. Here we show that synthetic Sex combs reduced (Scr) genes that encode the Scr C terminus containing the homedomain (HD) and YPWM motif (Scr-HD) are functional in vivo. Synthetic Scr-HD peptides can induce ectopic salivary glands in the embryo and homeotic transformations in the adult fly, act as transcriptional activators and repressors during development, and participate in protein-protein interactions. Their transformation capacity was found to be enhanced over their full-length counterpart and mutations known to transform the full-length protein into constitutively active or inactive variants behaved accordingly in the synthetic peptides. Our results show that synthetic Scr-HD genes are sufficient for homeotic function in Drosophila and suggest that the N terminus of Scr has a role in transcriptional potency, rather than specificity. We also demonstrate that synthetic peptides behave largely in a predictable way, by exhibiting Scr-specific phenotypes throughout development, which makes them an important tool for synthetic biology. | lld:pubmed |
| pubmed-article:20147626 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20147626 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20147626 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20147626 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20147626 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20147626 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20147626 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20147626 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20147626 | pubmed:issn | 1091-6490 | lld:pubmed |
| pubmed-article:20147626 | pubmed:author | pubmed-author:GehringWalter... | lld:pubmed |
| pubmed-article:20147626 | pubmed:author | pubmed-author:RiglerRudolfR | lld:pubmed |
| pubmed-article:20147626 | pubmed:author | pubmed-author:TereniusLarsL | lld:pubmed |
| pubmed-article:20147626 | pubmed:author | pubmed-author:AdachiYoshits... | lld:pubmed |
| pubmed-article:20147626 | pubmed:author | pubmed-author:VukojevicVlad... | lld:pubmed |
| pubmed-article:20147626 | pubmed:author | pubmed-author:PapadopoulosD... | lld:pubmed |
| pubmed-article:20147626 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20147626 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:20147626 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:20147626 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20147626 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20147626 | pubmed:pagination | 4087-92 | lld:pubmed |
| pubmed-article:20147626 | pubmed:dateRevised | 2010-9-3 | lld:pubmed |
| pubmed-article:20147626 | pubmed:meshHeading | pubmed-meshheading:20147626... | lld:pubmed |
| pubmed-article:20147626 | pubmed:meshHeading | pubmed-meshheading:20147626... | lld:pubmed |
| pubmed-article:20147626 | pubmed:meshHeading | pubmed-meshheading:20147626... | lld:pubmed |
| pubmed-article:20147626 | pubmed:meshHeading | pubmed-meshheading:20147626... | lld:pubmed |
| pubmed-article:20147626 | pubmed:meshHeading | pubmed-meshheading:20147626... | lld:pubmed |
| pubmed-article:20147626 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20147626 | pubmed:articleTitle | Function and specificity of synthetic Hox transcription factors in vivo. | lld:pubmed |
| pubmed-article:20147626 | pubmed:affiliation | Department of Cell Biology, Biozentrum, University of Basel, 4056 Basel, Switzerland. | lld:pubmed |
| pubmed-article:20147626 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20147626 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:31000 | entrezgene:pubmed | pubmed-article:20147626 | lld:entrezgene |
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| entrez-gene:37973 | entrezgene:pubmed | pubmed-article:20147626 | lld:entrezgene |
| entrez-gene:40833 | entrezgene:pubmed | pubmed-article:20147626 | lld:entrezgene |
| entrez-gene:40835 | entrezgene:pubmed | pubmed-article:20147626 | lld:entrezgene |
| entrez-gene:40962 | entrezgene:pubmed | pubmed-article:20147626 | lld:entrezgene |
| entrez-gene:41273 | entrezgene:pubmed | pubmed-article:20147626 | lld:entrezgene |
| entrez-gene:43023 | entrezgene:pubmed | pubmed-article:20147626 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:20147626 | lld:pubmed |
