| pubmed-article:20147530 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20147530 | lifeskim:mentions | umls-concept:C0001675 | lld:lifeskim |
| pubmed-article:20147530 | lifeskim:mentions | umls-concept:C0206745 | lld:lifeskim |
| pubmed-article:20147530 | lifeskim:mentions | umls-concept:C0814002 | lld:lifeskim |
| pubmed-article:20147530 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:20147530 | lifeskim:mentions | umls-concept:C0023816 | lld:lifeskim |
| pubmed-article:20147530 | lifeskim:mentions | umls-concept:C1172779 | lld:lifeskim |
| pubmed-article:20147530 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:20147530 | lifeskim:mentions | umls-concept:C0392756 | lld:lifeskim |
| pubmed-article:20147530 | lifeskim:mentions | umls-concept:C0439784 | lld:lifeskim |
| pubmed-article:20147530 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:20147530 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20147530 | pubmed:dateCreated | 2010-2-11 | lld:pubmed |
| pubmed-article:20147530 | pubmed:abstractText | Endocannabinoids (eCBs) function as retrograde signaling molecules at synapses throughout the brain, regulate axonal growth and guidance during development, and drive adult neurogenesis. There remains a lack of genetic evidence as to the identity of the enzyme(s) responsible for the synthesis of eCBs in the brain. Diacylglycerol lipase-alpha (DAGLalpha) and -beta (DAGLbeta) synthesize 2-arachidonoyl-glycerol (2-AG), the most abundant eCB in the brain. However, their respective contribution to this and to eCB signaling has not been tested. In the present study, we show approximately 80% reductions in 2-AG levels in the brain and spinal cord in DAGLalpha(-/-) mice and a 50% reduction in the brain in DAGLbeta(-/-) mice. In contrast, DAGLbeta plays a more important role than DAGLalpha in regulating 2-AG levels in the liver, with a 90% reduction seen in DAGLbeta(-/-) mice. Levels of arachidonic acid decrease in parallel with 2-AG, suggesting that DAGL activity controls the steady-state levels of both lipids. In the hippocampus, the postsynaptic release of an eCB results in the transient suppression of GABA-mediated transmission at inhibitory synapses; we now show that this form of synaptic plasticity is completely lost in DAGLalpha(-/-) animals and relatively unaffected in DAGLbeta(-/-) animals. Finally, we show that the control of adult neurogenesis in the hippocampus and subventricular zone is compromised in the DAGLalpha(-/-) and/or DAGLbeta(-/-) mice. These findings provide the first evidence that DAGLalpha is the major biosynthetic enzyme for 2-AG in the nervous system and reveal an essential role for this enzyme in regulating retrograde synaptic plasticity and adult neurogenesis. | lld:pubmed |
| pubmed-article:20147530 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20147530 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20147530 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20147530 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20147530 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20147530 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20147530 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20147530 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20147530 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20147530 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20147530 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20147530 | pubmed:issn | 1529-2401 | lld:pubmed |
| pubmed-article:20147530 | pubmed:author | pubmed-author:TengC TCT | lld:pubmed |
| pubmed-article:20147530 | pubmed:author | pubmed-author:WilliamsGaret... | lld:pubmed |
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| pubmed-article:20147530 | pubmed:author | pubmed-author:GaoYingY | lld:pubmed |
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| pubmed-article:20147530 | pubmed:author | pubmed-author:WalshFrank... | lld:pubmed |
| pubmed-article:20147530 | pubmed:author | pubmed-author:BatesBrianB | lld:pubmed |
| pubmed-article:20147530 | pubmed:author | pubmed-author:ZhangMei-YiMY | lld:pubmed |
| pubmed-article:20147530 | pubmed:author | pubmed-author:SamadTarek... | lld:pubmed |
| pubmed-article:20147530 | pubmed:author | pubmed-author:DengKangwenK | lld:pubmed |
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| pubmed-article:20147530 | pubmed:author | pubmed-author:MarkLillyL | lld:pubmed |
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| pubmed-article:20147530 | pubmed:author | pubmed-author:PieslaMichael... | lld:pubmed |
| pubmed-article:20147530 | pubmed:author | pubmed-author:LuPeiminP | lld:pubmed |
| pubmed-article:20147530 | pubmed:author | pubmed-author:GoncalvesMari... | lld:pubmed |
| pubmed-article:20147530 | pubmed:author | pubmed-author:ReisenbergMel... | lld:pubmed |
| pubmed-article:20147530 | pubmed:author | pubmed-author:KouranovaEvgu... | lld:pubmed |
| pubmed-article:20147530 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20147530 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:20147530 | pubmed:volume | 30 | lld:pubmed |
| pubmed-article:20147530 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20147530 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20147530 | pubmed:pagination | 2017-24 | lld:pubmed |
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| pubmed-article:20147530 | pubmed:meshHeading | pubmed-meshheading:20147530... | lld:pubmed |
| pubmed-article:20147530 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20147530 | pubmed:articleTitle | Loss of retrograde endocannabinoid signaling and reduced adult neurogenesis in diacylglycerol lipase knock-out mice. | lld:pubmed |
| pubmed-article:20147530 | pubmed:affiliation | Neuroscience Discovery, Pfizer Research, Princeton, New Jersey 08543, and Wolfson Centre for Age-Related Diseases, King's College London, London SE1 1UL, United Kingdom. | lld:pubmed |
| pubmed-article:20147530 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20147530 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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