Linked Life Data

20145726

Source:http://linkedlifedata.com/resource/pubmed/id/20145726

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pubmed-article:20145726pubmed:abstractTextHistone deacetylase inhibitors (HDACi) have become a promising new avenue for cancer therapy, and many are currently in Phase I/II clinical trials for various tumor types. In the present study, we show that apoptosis induction and histone alterations by PCI-24781, a novel hydroxamic acid-based HDAC inhibitor, require caspase-8 and the adaptor molecule, Fas-associated death domain (FADD), in acute leukemia cells. PCI-24781 treatment also causes an increase in superoxide levels, which has been reported for other HDACi. However, an antioxidant does not reverse histone alterations caused by PCI-24781, indicating that ROS generation is likely downstream of the effects that PCI-24781 exerts on histone H3. Taken together, these results provide insight into the mechanism of apoptosis induction by PCI-24781 in leukemia by highlighting the roles of caspase-8, FADD and increased superoxide levels.lld:pubmed
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pubmed-article:20145726pubmed:authorpubmed-author:ChandraJoyaJlld:pubmed
pubmed-article:20145726pubmed:authorpubmed-author:GaoShanSlld:pubmed
pubmed-article:20145726pubmed:authorpubmed-author:MillerClaudia...lld:pubmed
pubmed-article:20145726pubmed:authorpubmed-author:SirisawadMint...lld:pubmed
pubmed-article:20145726pubmed:authorpubmed-author:Balasubramani...lld:pubmed
pubmed-article:20145726pubmed:authorpubmed-author:WhelerJennife...lld:pubmed
pubmed-article:20145726pubmed:authorpubmed-author:NilsaRivera-D...lld:pubmed
pubmed-article:20145726pubmed:authorpubmed-author:FulbrightJoyJlld:pubmed
pubmed-article:20145726pubmed:authorpubmed-author:GonzalesCarol...lld:pubmed
pubmed-article:20145726pubmed:authorpubmed-author:SteggerdaSusa...lld:pubmed
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pubmed-article:20145726pubmed:volume2010lld:pubmed
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pubmed-article:20145726pubmed:pagination207420lld:pubmed
pubmed-article:20145726pubmed:dateRevised2010-9-27lld:pubmed
pubmed-article:20145726pubmed:year2010lld:pubmed
pubmed-article:20145726pubmed:articleTitlePCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells.lld:pubmed
pubmed-article:20145726pubmed:affiliationDepartment of Pediatrics Research, Children's Cancer Hospital, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA.lld:pubmed
pubmed-article:20145726pubmed:publicationTypeJournal Articlelld:pubmed