pubmed-article:20145546 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:20145546 | lifeskim:mentions | umls-concept:C0008976 | lld:lifeskim |
pubmed-article:20145546 | lifeskim:mentions | umls-concept:C0021083 | lld:lifeskim |
pubmed-article:20145546 | lifeskim:mentions | umls-concept:C0079460 | lld:lifeskim |
pubmed-article:20145546 | lifeskim:mentions | umls-concept:C0079731 | lld:lifeskim |
pubmed-article:20145546 | lifeskim:mentions | umls-concept:C0439682 | lld:lifeskim |
pubmed-article:20145546 | lifeskim:mentions | umls-concept:C0393022 | lld:lifeskim |
pubmed-article:20145546 | lifeskim:mentions | umls-concept:C0205390 | lld:lifeskim |
pubmed-article:20145546 | lifeskim:mentions | umls-concept:C1327897 | lld:lifeskim |
pubmed-article:20145546 | pubmed:issue | 2 | lld:pubmed |
pubmed-article:20145546 | pubmed:dateCreated | 2010-2-24 | lld:pubmed |
pubmed-article:20145546 | pubmed:abstractText | We evaluated the efficacy and safety of patient-specific immunotherapy with mitumprotimut-T idiotype keyhole limpet hemocyanin and granulocyte-monocyte colony-stimulating factor (GM-CSF) following rituximab in patients with follicular B-cell lymphoma. Patients with previously untreated or relapsed/refractory CD20+ follicular lymphoma received 4 weekly infusions of rituximab and those with a complete response (CR), partial response (PR), or stable disease received mitumprotimut-T and GM-CSF injections subcutaneously. Courses were given monthly for 6 doses, every 2 months for 6 doses, and then every 3 months until disease progression. Computed tomography scans were obtained every 3 to 6 months and reviewed centrally. The primary endpoint was event-free survival (EFS). Among 103 patients treated with rituximab, 92 (54 relapsed/refractory and 38 previously untreated) received mitumprotimut-T/GM-CSF; median age was 53 years, 91% had stage III to IV disease, and 59% had failed earlier therapy. The premitumprotimut-T objective response rate was 47% (2 CRs, 41 PRs). During the mitumprotimut-T treatment phase, 16 patients converted to CR resulting in an overall objective response rate of 60% (18 CRs, 37 PRs). Median EFS was 15.2, 20.8, and 13.5 months for all, treatment-naive, and relapsed/refractory disease patients, respectively. Anti-Id cellular immune responses were detected in 13 of 18 (72%) patients and humoral immune responses in 17 of 83 (20%) patients. Adverse events were usually mild-to-moderate. The most common adverse event was injection site reactions. Mitumprotimut-T/GM-CSF-induced anti-Id cellular immune responses in most patients. The occurrence of late CRs and favorable EFS suggested a clinical benefit of active immunotherapy and led to a placebo-controlled phase 3 trial. | lld:pubmed |
pubmed-article:20145546 | pubmed:language | eng | lld:pubmed |
pubmed-article:20145546 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20145546 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:20145546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20145546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20145546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20145546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20145546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20145546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20145546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20145546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20145546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20145546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20145546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20145546 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20145546 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:20145546 | pubmed:issn | 1537-4513 | lld:pubmed |
pubmed-article:20145546 | pubmed:author | pubmed-author:WiernikPeter... | lld:pubmed |
pubmed-article:20145546 | pubmed:author | pubmed-author:RosenfeltFred... | lld:pubmed |
pubmed-article:20145546 | pubmed:author | pubmed-author:WinterJane... | lld:pubmed |
pubmed-article:20145546 | pubmed:author | pubmed-author:KoçOmer NON | lld:pubmed |
pubmed-article:20145546 | pubmed:author | pubmed-author:StewartMorgan... | lld:pubmed |
pubmed-article:20145546 | pubmed:author | pubmed-author:BenderJohn... | lld:pubmed |
pubmed-article:20145546 | pubmed:author | pubmed-author:GhalieRichard... | lld:pubmed |
pubmed-article:20145546 | pubmed:author | pubmed-author:RedfernCharle... | lld:pubmed |
pubmed-article:20145546 | pubmed:author | pubmed-author:CarterWilliam... | lld:pubmed |
pubmed-article:20145546 | pubmed:author | pubmed-author:GoldDan PDP | lld:pubmed |
pubmed-article:20145546 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:20145546 | pubmed:volume | 33 | lld:pubmed |
pubmed-article:20145546 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:20145546 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:20145546 | pubmed:pagination | 178-84 | lld:pubmed |
pubmed-article:20145546 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
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pubmed-article:20145546 | pubmed:articleTitle | A phase 2 trial of immunotherapy with mitumprotimut-T (Id-KLH) and GM-CSF following rituximab in follicular B-cell lymphoma. | lld:pubmed |
pubmed-article:20145546 | pubmed:affiliation | Department of Regional Oncology, Cleveland Clinic, Beachwood, OH 44122, USA. KOCO@ccf.org | lld:pubmed |
pubmed-article:20145546 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:20145546 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
pubmed-article:20145546 | pubmed:publicationType | Clinical Trial, Phase II | lld:pubmed |