| pubmed-article:20145129 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20145129 | lifeskim:mentions | umls-concept:C0006142 | lld:lifeskim |
| pubmed-article:20145129 | lifeskim:mentions | umls-concept:C0034840 | lld:lifeskim |
| pubmed-article:20145129 | lifeskim:mentions | umls-concept:C0040648 | lld:lifeskim |
| pubmed-article:20145129 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:20145129 | lifeskim:mentions | umls-concept:C0279025 | lld:lifeskim |
| pubmed-article:20145129 | lifeskim:mentions | umls-concept:C0678723 | lld:lifeskim |
| pubmed-article:20145129 | lifeskim:mentions | umls-concept:C1415675 | lld:lifeskim |
| pubmed-article:20145129 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:20145129 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:20145129 | lifeskim:mentions | umls-concept:C0205202 | lld:lifeskim |
| pubmed-article:20145129 | lifeskim:mentions | umls-concept:C0458003 | lld:lifeskim |
| pubmed-article:20145129 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20145129 | pubmed:dateCreated | 2010-2-16 | lld:pubmed |
| pubmed-article:20145129 | pubmed:abstractText | Mechanisms of acquired resistance to endocrine therapy in breast cancer, a major clinical challenge, are poorly understood. We have used a mass spectrometry-based screen to identify proteins that are associated with the endocrine-resistant phenotype. In this study, we report the identification of a novel pathway of resistance to endocrine therapy involving interactions of the developmental transcription HOXC11 with the steroid receptor coactivator protein SRC-1, which is a strong predictor of reduced disease-free survival in breast cancer patients. HOXC11 and SRC-1 cooperate to regulate expression of the calcium-binding protein S100beta in resistant breast cancer cells. Nuclear HOXC11 and S100beta were found to strongly predict poor disease-free survival in breast cancer patients (n = 560; hazard ratios: 5.79 and 5.82, respectively; P < 0.0001). Elevated serum levels of S100beta detected in patients also predicted reduced disease-free survival (n = 80; hazard ratio: 5.3; P = 0.004). Our findings define a biomolecular interaction network that drives an adaptive response to endocrine therapy with negative consequences for survival in breast cancer. | lld:pubmed |
| pubmed-article:20145129 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20145129 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20145129 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20145129 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20145129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20145129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20145129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20145129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20145129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20145129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20145129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20145129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20145129 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20145129 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20145129 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20145129 | pubmed:issn | 1538-7445 | lld:pubmed |
| pubmed-article:20145129 | pubmed:author | pubmed-author:YoungLeonie... | lld:pubmed |
| pubmed-article:20145129 | pubmed:author | pubmed-author:HillArnold... | lld:pubmed |
| pubmed-article:20145129 | pubmed:author | pubmed-author:O... | lld:pubmed |
| pubmed-article:20145129 | pubmed:author | pubmed-author:McIlroyMarieM | lld:pubmed |
| pubmed-article:20145129 | pubmed:author | pubmed-author:PenningtonSte... | lld:pubmed |
| pubmed-article:20145129 | pubmed:author | pubmed-author:McCartanDamia... | lld:pubmed |
| pubmed-article:20145129 | pubmed:author | pubmed-author:EarlySarahS | lld:pubmed |
| pubmed-article:20145129 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20145129 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20145129 | pubmed:volume | 70 | lld:pubmed |
| pubmed-article:20145129 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20145129 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20145129 | pubmed:pagination | 1585-94 | lld:pubmed |
| pubmed-article:20145129 | pubmed:dateRevised | 2010-4-16 | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:meshHeading | pubmed-meshheading:20145129... | lld:pubmed |
| pubmed-article:20145129 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20145129 | pubmed:articleTitle | Interaction of developmental transcription factor HOXC11 with steroid receptor coactivator SRC-1 mediates resistance to endocrine therapy in breast cancer [corrected]. | lld:pubmed |
| pubmed-article:20145129 | pubmed:affiliation | Endocrine Oncology Research, Department of Surgery, Royal College of Surgeons in Ireland, Dublin D2, Ireland. | lld:pubmed |
| pubmed-article:20145129 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20145129 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:20145129 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:8648 | entrezgene:pubmed | pubmed-article:20145129 | lld:entrezgene |
| entrez-gene:3227 | entrezgene:pubmed | pubmed-article:20145129 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20145129 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20145129 | lld:entrezgene |
