| pubmed-article:20145100 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20145100 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:20145100 | lifeskim:mentions | umls-concept:C0205474 | lld:lifeskim |
| pubmed-article:20145100 | lifeskim:mentions | umls-concept:C0020964 | lld:lifeskim |
| pubmed-article:20145100 | lifeskim:mentions | umls-concept:C0002826 | lld:lifeskim |
| pubmed-article:20145100 | lifeskim:mentions | umls-concept:C1265425 | lld:lifeskim |
| pubmed-article:20145100 | lifeskim:mentions | umls-concept:C0009017 | lld:lifeskim |
| pubmed-article:20145100 | lifeskim:mentions | umls-concept:C2825097 | lld:lifeskim |
| pubmed-article:20145100 | lifeskim:mentions | umls-concept:C0728938 | lld:lifeskim |
| pubmed-article:20145100 | lifeskim:mentions | umls-concept:C1880022 | lld:lifeskim |
| pubmed-article:20145100 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:20145100 | pubmed:dateCreated | 2010-3-17 | lld:pubmed |
| pubmed-article:20145100 | pubmed:abstractText | Hookworm glutathione S-transferases (GSTs) are critical for parasite blood feeding and survival and represent potential targets for vaccination. Three cDNAs, each encoding a full-length GST protein from the human hookworm Necator americanus (and designated Na-GST-1, Na-GST-2, and Na-GST-3, respectively) were isolated from cDNA based on their sequence similarity to Ac-GST-1, a GST from the dog hookworm Ancylostoma caninum. The open reading frames of the three N. americanus GSTs each contain 206 amino acids with 51% to 69% sequence identity between each other and Ac-GST-1. Sequence alignment with GSTs from other organisms shows that the three Na-GSTs belong to a nematode-specific nu-class GST family. All three Na-GSTs, when expressed in Pichia pastoris, exhibited low lipid peroxidase and glutathione-conjugating enzymatic activities but high heme-binding capacities, and they may be involved in the detoxification and/or transport of heme. In two separate vaccine trials, recombinant Na-GST-1 formulated with Alhydrogel elicited 32 and 39% reductions in adult hookworm burdens (P < 0.05) following N. americanus larval challenge relative to the results for a group immunized with Alhydrogel alone. In contrast, no protection was observed in vaccine trials with Na-GST-2 or Na-GST-3. On the basis of these and other preclinical data, Na-GST-1 is under possible consideration for further vaccine development. | lld:pubmed |
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| pubmed-article:20145100 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20145100 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20145100 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20145100 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20145100 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20145100 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:20145100 | pubmed:issn | 1098-5522 | lld:pubmed |
| pubmed-article:20145100 | pubmed:author | pubmed-author:LustigmanSara... | lld:pubmed |
| pubmed-article:20145100 | pubmed:author | pubmed-author:OksovYelenaY | lld:pubmed |
| pubmed-article:20145100 | pubmed:author | pubmed-author:LoukasAlexA | lld:pubmed |
| pubmed-article:20145100 | pubmed:author | pubmed-author:ZhanBinB | lld:pubmed |
| pubmed-article:20145100 | pubmed:author | pubmed-author:HotezPeterP | lld:pubmed |
