Linked Life Data

20144764

Source:http://linkedlifedata.com/resource/pubmed/id/20144764

Statements in which the resource exists.
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pubmed-article:20144764pubmed:abstractTextPrions are proteins that can assume at least two distinct conformational states, one of which is dominant and self-perpetuating. Previously we found that a translation regulator CPEB from Aplysia, ApCPEB, that stabilizes activity-dependent changes in synaptic efficacy can display prion-like properties in yeast. Here we find that, when exogenously expressed in sensory neurons, ApCPEB can form an amyloidogenic self-sustaining multimer, consistent with it being a prion-like protein. In addition, we find that conversion of both the exogenous and the endogenous ApCPEB to the multimeric state is enhanced by the neurotransmitter serotonin and that an antibody that recognizes preferentially the multimeric ApCPEB blocks persistence of synaptic facilitation. These results are consistent with the idea that ApCPEB can act as a self-sustaining prion-like protein in the nervous system and thereby might allow the activity-dependent change in synaptic efficacy to persist for long periods of time.lld:pubmed
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pubmed-article:20144764pubmed:authorpubmed-author:KandelEric...lld:pubmed
pubmed-article:20144764pubmed:authorpubmed-author:ChoiYun-BeomY...lld:pubmed
pubmed-article:20144764pubmed:authorpubmed-author:SiKausikKlld:pubmed
pubmed-article:20144764pubmed:authorpubmed-author:MajumdarAmita...lld:pubmed
pubmed-article:20144764pubmed:authorpubmed-author:White-Grindle...lld:pubmed
pubmed-article:20144764pubmed:copyrightInfo2010 Elsevier Inc. All rights reserved.lld:pubmed
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pubmed-article:20144764pubmed:pagination421-35lld:pubmed
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pubmed-article:20144764pubmed:articleTitleAplysia CPEB can form prion-like multimers in sensory neurons that contribute to long-term facilitation.lld:pubmed
pubmed-article:20144764pubmed:affiliationStowers Institute for Medical Research, 1000 East 50th Street, Kansas City, MO 64110, USA. ksi@Stowers-Institute.orglld:pubmed
pubmed-article:20144764pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20144764pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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