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pubmed-article:20144663pubmed:abstractTextTaenia solium cysticerci are a major cause of human seizures and epilepsy in the world. In the gastrointestinal tract of infected individuals, taeniid eggs release the oncospheres, which are then activated by intestinal stimuli, getting ready to penetrate the gut wall and reach distant locations where they transform in cysticerci. Information about oncospheral molecules is scarce, and elucidation of the oncosphere proteome could help understanding the host-parasite relationship during the first steps of infection. In this study, using liquid chromatography and tandem mass spectrometry (LC-MS/MS) analysis, we could identify a set of oncospheral proteins involved in adhesion, protein folding, detoxification and proteolysis, among others. In addition, we have characterized one of the identified molecules, the parasite 14-3-3, by immunoblot and immunolocalization. The identification of these oncospheral proteins represents the first step to elucidate their specific roles in the biology of the host-parasite relationship.lld:pubmed
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pubmed-article:20144663pubmed:authorpubmed-author:PalmaSSlld:pubmed
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pubmed-article:20144663pubmed:authorpubmed-author:GarciaH HHHlld:pubmed
pubmed-article:20144663pubmed:authorpubmed-author:GonzalezA EAElld:pubmed
pubmed-article:20144663pubmed:authorpubmed-author:Hernández-Gon...lld:pubmed
pubmed-article:20144663pubmed:authorpubmed-author:Siles-LucasMMlld:pubmed
pubmed-article:20144663pubmed:authorpubmed-author:Cysticercosis...lld:pubmed
pubmed-article:20144663pubmed:authorpubmed-author:SantivañezS...lld:pubmed
pubmed-article:20144663pubmed:authorpubmed-author:ChileNNlld:pubmed
pubmed-article:20144663pubmed:copyrightInfo(c) 2010 Elsevier B.V. All rights reserved.lld:pubmed
pubmed-article:20144663pubmed:issnTypeElectroniclld:pubmed
pubmed-article:20144663pubmed:volume171lld:pubmed
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pubmed-article:20144663pubmed:pagination32-9lld:pubmed
pubmed-article:20144663pubmed:dateRevised2011-7-28lld:pubmed
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pubmed-article:20144663pubmed:articleTitleProteomic study of activated Taenia solium oncospheres.lld:pubmed
pubmed-article:20144663pubmed:affiliationCysticercosis Unit, Instituto Nacional de Ciencias Neurológicas, Lima, Peru.lld:pubmed
pubmed-article:20144663pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20144663pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
pubmed-article:20144663pubmed:publicationTypeResearch Support, N.I.H., Extramurallld:pubmed