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pubmed-article:20143438pubmed:abstractText: Glioma cells secrete glutamate and also express alpha-amino-3-hydroxy-5 methyl-4-isoxazolepropionate (AMPA) glutamate receptors, which contribute to the proliferation, migration, and neurotoxicity of malignant gliomas. Talampanel is an oral AMPA receptor inhibitor with excellent central nervous system penetration and good tolerability in clinical trials for epilepsy and other neurologic disorders.lld:pubmed
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pubmed-article:20143438pubmed:articleTitlePhase 2 trial of talampanel, a glutamate receptor inhibitor, for adults with recurrent malignant gliomas.lld:pubmed
pubmed-article:20143438pubmed:affiliationNeuro-Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.lld:pubmed
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