| pubmed-article:20142427 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20142427 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
| pubmed-article:20142427 | lifeskim:mentions | umls-concept:C0021761 | lld:lifeskim |
| pubmed-article:20142427 | lifeskim:mentions | umls-concept:C0254610 | lld:lifeskim |
| pubmed-article:20142427 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:20142427 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:20142427 | lifeskim:mentions | umls-concept:C1515021 | lld:lifeskim |
| pubmed-article:20142427 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:20142427 | lifeskim:mentions | umls-concept:C1709634 | lld:lifeskim |
| pubmed-article:20142427 | lifeskim:mentions | umls-concept:C2728259 | lld:lifeskim |
| pubmed-article:20142427 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20142427 | pubmed:dateCreated | 2010-2-16 | lld:pubmed |
| pubmed-article:20142427 | pubmed:abstractText | The natural cytotoxicity receptor NKp46 (encoded by Ncr1) was recently shown to identify a subset of noncytotoxic, Rag-independent gut lymphocytes that express the transcription factor Rorc, produce interleukin (IL)-22, and provide innate immune protection at the intestinal mucosa. Intestinal CD3(-)NKp46(+) cells are phenotypically heterogeneous, comprising a minority subset that resembles classical mature splenic natural killer (NK) cells (NK1.1(+), Ly49(+)) but also a large CD127(+)NK1.1(-) subset of lymphoid tissue inducer (LTi)-like Rorc(+) cells that has been proposed to include NK cell precursors. We investigated the developmental relationships between these intestinal CD3(-)NKp46(+) subsets. Gut CD3(-)NKp46(+) cells were related to LTi and NK cells in requiring the transcriptional inhibitor Id2 for normal development. Overexpression of IL-15 in intestinal epithelial cells expanded NK1.1(+) cells within the gut but had no effect on absolute numbers of the CD127(+)NK1.1(-)Rorc(+) subset of CD3(-)NKp46(+) cells. In contrast, IL-7 deficiency strongly reduced the overall numbers of CD3(-)NKp46(+)NK1.1(-) cells that express Rorc and produce IL-22 but failed to restrict homeostasis of classical intestinal NK1.1(+) cells. Finally, in vivo fate-mapping experiments demonstrated that intestinal NK1.1(+)CD127(-) cells are not the progeny of Rorc-expressing progenitors, indicating that CD127(+)NK1.1(-)Rorc(+) cells are not canonical NK cell precursors. These studies highlight the independent cytokine regulation of functionally diverse intestinal NKp46(+) cell subsets. | lld:pubmed |
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| pubmed-article:20142427 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20142427 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20142427 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20142427 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20142427 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20142427 | pubmed:issn | 1540-9538 | lld:pubmed |
| pubmed-article:20142427 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:20142427 | pubmed:author | pubmed-author:SawaShinichir... | lld:pubmed |
| pubmed-article:20142427 | pubmed:author | pubmed-author:VieiraPauloP | lld:pubmed |
| pubmed-article:20142427 | pubmed:author | pubmed-author:VosshenrichCh... | lld:pubmed |
| pubmed-article:20142427 | pubmed:author | pubmed-author:EberlGerardG | lld:pubmed |
| pubmed-article:20142427 | pubmed:author | pubmed-author:Lesjean-Potti... | lld:pubmed |
| pubmed-article:20142427 | pubmed:author | pubmed-author:Satoh-Takayam... | lld:pubmed |
| pubmed-article:20142427 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20142427 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20142427 | pubmed:volume | 207 | lld:pubmed |
| pubmed-article:20142427 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20142427 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20142427 | pubmed:pagination | 273-80 | lld:pubmed |
| pubmed-article:20142427 | pubmed:dateRevised | 2010-9-28 | lld:pubmed |
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