| pubmed-article:20140011 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20140011 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:20140011 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:20140011 | lifeskim:mentions | umls-concept:C0409974 | lld:lifeskim |
| pubmed-article:20140011 | lifeskim:mentions | umls-concept:C2243049 | lld:lifeskim |
| pubmed-article:20140011 | lifeskim:mentions | umls-concept:C0205217 | lld:lifeskim |
| pubmed-article:20140011 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:20140011 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:20140011 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:20140011 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20140011 | pubmed:dateCreated | 2010-3-1 | lld:pubmed |
| pubmed-article:20140011 | pubmed:abstractText | Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease. Innate and adaptive immunity cooperatively contribute to the development of SLE. Antigen-presenting cells (APCs) have been suggested to link innate and adaptive immunity. T-cell immunoglobulin- and mucin-domain-containing molecule-4 (Tim-4; also known as Timd4), expressed primarily on the surface of APCs, is a member of the TIM family, a recently described group of molecules that have received much attention as potential regulators of the immune system. In this study, we used quantitative real-time reverse transcription-polymerase chain reaction to examine the mRNA expression of Tim-4 in peripheral blood mononuclear cells (PBMCs) from SLE patients and further analyzed the correlation between the expression of Tim-4 and Tim-1 (a potential ligand for Tim-4) in PBMCs and serum tumor necrosis factor (TNF)-alpha levels. The results showed that Tim-4 mRNA expression in PBMCs was significantly higher in SLE patients than in healthy controls, especially those patients in the active phase of disease. Moreover, Tim-4 mRNA levels were closely correlated with Tim-1 mRNA levels in PBMCs and with serum TNF-alpha levels in SLE patients but not in the control group. Taken together, these results demonstrate that Tim-4 may be involved in the pathogenesis of SLE. | lld:pubmed |
| pubmed-article:20140011 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20140011 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20140011 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20140011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20140011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20140011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20140011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20140011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20140011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20140011 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20140011 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20140011 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20140011 | pubmed:issn | 2042-0226 | lld:pubmed |
| pubmed-article:20140011 | pubmed:author | pubmed-author:LiuPengP | lld:pubmed |
| pubmed-article:20140011 | pubmed:author | pubmed-author:GuoChunC | lld:pubmed |
| pubmed-article:20140011 | pubmed:author | pubmed-author:MaChunhongC | lld:pubmed |
| pubmed-article:20140011 | pubmed:author | pubmed-author:ZhangLiningL | lld:pubmed |
| pubmed-article:20140011 | pubmed:author | pubmed-author:ZhaoPeiqingP | lld:pubmed |
| pubmed-article:20140011 | pubmed:author | pubmed-author:LiangXiaohong... | lld:pubmed |
| pubmed-article:20140011 | pubmed:author | pubmed-author:GaoLifenL | lld:pubmed |
| pubmed-article:20140011 | pubmed:author | pubmed-author:XuLiyunL | lld:pubmed |
| pubmed-article:20140011 | pubmed:author | pubmed-author:QiJianniJ | lld:pubmed |
| pubmed-article:20140011 | pubmed:author | pubmed-author:WangPimingP | lld:pubmed |
| pubmed-article:20140011 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20140011 | pubmed:volume | 7 | lld:pubmed |
| pubmed-article:20140011 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20140011 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20140011 | pubmed:pagination | 152-6 | lld:pubmed |
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| pubmed-article:20140011 | pubmed:meshHeading | pubmed-meshheading:20140011... | lld:pubmed |
| pubmed-article:20140011 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20140011 | pubmed:articleTitle | Increased expression of human T-cell immunoglobulin- and mucin-domain-containing molecule-4 in peripheral blood mononuclear cells from patients with system lupus erythematosus. | lld:pubmed |
| pubmed-article:20140011 | pubmed:affiliation | Institute of Immunology, Shandong University School of Medicine, Jinan, China. | lld:pubmed |
| pubmed-article:20140011 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20140011 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:91937 | entrezgene:pubmed | pubmed-article:20140011 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20140011 | lld:entrezgene |
