| pubmed-article:20134034 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20134034 | lifeskim:mentions | umls-concept:C0004096 | lld:lifeskim |
| pubmed-article:20134034 | lifeskim:mentions | umls-concept:C0231335 | lld:lifeskim |
| pubmed-article:20134034 | lifeskim:mentions | umls-concept:C0242606 | lld:lifeskim |
| pubmed-article:20134034 | lifeskim:mentions | umls-concept:C0017337 | lld:lifeskim |
| pubmed-article:20134034 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:20134034 | pubmed:dateCreated | 2010-2-5 | lld:pubmed |
| pubmed-article:20134034 | pubmed:abstractText | There is increasing evidence that bronchial asthma is associated with increased oxidative stress. Reactive oxygen species are produced in each organism as by-products of several essential reactions and can damage biomolecules. Asthma is a complex chronic inflammatory disorder of the airways, with many candidate genes suspected as being important in its development. Glutathione S-transferase (GST) is such a gene due to its role in protection against oxidative stress. In the present study, we examined the hypothesis that increased oxidative stress and polymorphism in the GST-T1 gene are associated with childhood asthma. We found that the amount of sulfhydryl groups significantly decreased and the content of thiobarbituric acid-reactive substances increased in the group of asthmatic children, compared with healthy controls. The GST-T1 null genotype was more frequent among the asthma patients. These results suggest that the GST-T1 null genotype and increased oxidative stress may play a role in the asthma pathogenesis in children. | lld:pubmed |
| pubmed-article:20134034 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20134034 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20134034 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20134034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20134034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20134034 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20134034 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20134034 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:20134034 | pubmed:issn | 1899-1505 | lld:pubmed |
| pubmed-article:20134034 | pubmed:author | pubmed-author:DobrotaDD | lld:pubmed |
| pubmed-article:20134034 | pubmed:author | pubmed-author:BanovcinPP | lld:pubmed |
| pubmed-article:20134034 | pubmed:author | pubmed-author:BabusikovaEE | lld:pubmed |
| pubmed-article:20134034 | pubmed:author | pubmed-author:JesenakMM | lld:pubmed |
| pubmed-article:20134034 | pubmed:author | pubmed-author:KirschnerovaR... | lld:pubmed |
| pubmed-article:20134034 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20134034 | pubmed:volume | 60 Suppl 5 | lld:pubmed |
| pubmed-article:20134034 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20134034 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20134034 | pubmed:pagination | 27-30 | lld:pubmed |
| pubmed-article:20134034 | pubmed:meshHeading | pubmed-meshheading:20134034... | lld:pubmed |
| pubmed-article:20134034 | pubmed:meshHeading | pubmed-meshheading:20134034... | lld:pubmed |
| pubmed-article:20134034 | pubmed:meshHeading | pubmed-meshheading:20134034... | lld:pubmed |
| pubmed-article:20134034 | pubmed:meshHeading | pubmed-meshheading:20134034... | lld:pubmed |
| pubmed-article:20134034 | pubmed:meshHeading | pubmed-meshheading:20134034... | lld:pubmed |
| pubmed-article:20134034 | pubmed:meshHeading | pubmed-meshheading:20134034... | lld:pubmed |
| pubmed-article:20134034 | pubmed:meshHeading | pubmed-meshheading:20134034... | lld:pubmed |
| pubmed-article:20134034 | pubmed:meshHeading | pubmed-meshheading:20134034... | lld:pubmed |
| pubmed-article:20134034 | pubmed:meshHeading | pubmed-meshheading:20134034... | lld:pubmed |
| pubmed-article:20134034 | pubmed:meshHeading | pubmed-meshheading:20134034... | lld:pubmed |
| pubmed-article:20134034 | pubmed:meshHeading | pubmed-meshheading:20134034... | lld:pubmed |
| pubmed-article:20134034 | pubmed:meshHeading | pubmed-meshheading:20134034... | lld:pubmed |
| pubmed-article:20134034 | pubmed:meshHeading | pubmed-meshheading:20134034... | lld:pubmed |
| pubmed-article:20134034 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:20134034 | pubmed:articleTitle | Association of oxidative stress and GST-T1 gene with childhood bronchial asthma. | lld:pubmed |
| pubmed-article:20134034 | pubmed:affiliation | Department of Medical Biochemistry, Comenius University in Bratislava, Jessenius Faculty of Medicine, Martin, Slovakia. eva.babusikova@gmail.com | lld:pubmed |
| pubmed-article:20134034 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20134034 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:20134034 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:2952 | entrezgene:pubmed | pubmed-article:20134034 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20134034 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20134034 | lld:entrezgene |
