Linked Life Data

20132954

Source:http://linkedlifedata.com/resource/pubmed/id/20132954

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pubmed-article:20132954pubmed:abstractTextMore effective vaccines against Toxoplasma gondii may contribute to the control of this pathogen that has major veterinary and public health significance. In this study, two recombinant plasmids pcDNA/TgSAG1 and pVAX/mIL-18 containing T. gondii SAG1 (TgSAG1) and murine cytokine interleukin-18 (IL-18) were evaluated for their ability to protect mice against T. gondii challenge. Mice were given two intramuscular immunizations 3 weeks apart, and challenged with T. gondii 3 weeks later. All animals vaccinated with pcDNA/TgSAG1 alone or with pVAX/mIL-18 developed specific anti-TLA (T. gondii lysate antigen) antibodies and specific lymphocyte proliferative responses. Co-injection of pVAX/mIL-18 significantly increased the production of IFN-gamma and IL-2. Further, challenge experiments showed that co-immunization with pVAX/mIL-18 significantly (P<0.05) increased the survival rate (60%), compared with pcDNA/TgSAG1 alone (40%). Therefore, codelivery of the IL-18-secreting plasmid potentiates the induction and maintenance of the type 1 helper T-cell immune response and may be a potent strategy for enhancing the protective efficacy of vaccines against T. gondii.lld:pubmed
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pubmed-article:20132954pubmed:authorpubmed-author:FengWeiWlld:pubmed
pubmed-article:20132954pubmed:authorpubmed-author:GaoHongweiHlld:pubmed
pubmed-article:20132954pubmed:authorpubmed-author:ShengLiqinLlld:pubmed
pubmed-article:20132954pubmed:authorpubmed-author:LiuQuanQlld:pubmed
pubmed-article:20132954pubmed:authorpubmed-author:ZhuXing-QuanX...lld:pubmed
pubmed-article:20132954pubmed:authorpubmed-author:JinHongtaoHlld:pubmed
pubmed-article:20132954pubmed:copyrightInfoCopyright 2010 Elsevier Ltd. All rights reserved.lld:pubmed
pubmed-article:20132954pubmed:issnTypeElectroniclld:pubmed
pubmed-article:20132954pubmed:volume89lld:pubmed
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pubmed-article:20132954pubmed:year2010lld:pubmed
pubmed-article:20132954pubmed:articleTitleThe protective effect of a Toxoplasma gondii SAG1 plasmid DNA vaccine in mice is enhanced with IL-18.lld:pubmed
pubmed-article:20132954pubmed:affiliationInstitute of Military Veterinary, Academy of Military Medical Sciences, Changchun 130062, Jilin Province, China. liuquan1973@hotmail.comlld:pubmed
pubmed-article:20132954pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20132954pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed