| pubmed-article:20130140 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20130140 | lifeskim:mentions | umls-concept:C0029246 | lld:lifeskim |
| pubmed-article:20130140 | lifeskim:mentions | umls-concept:C0230595 | lld:lifeskim |
| pubmed-article:20130140 | lifeskim:mentions | umls-concept:C2745900 | lld:lifeskim |
| pubmed-article:20130140 | lifeskim:mentions | umls-concept:C0450363 | lld:lifeskim |
| pubmed-article:20130140 | pubmed:issue | Pt 3 | lld:pubmed |
| pubmed-article:20130140 | pubmed:dateCreated | 2010-2-4 | lld:pubmed |
| pubmed-article:20130140 | pubmed:abstractText | Promyelocytic leukemia nuclear bodies (PML-NBs) are mobile subnuclear organelles formed by PML and Sp100 protein. They have been reported to have a role in transcription, DNA replication and repair, telomere lengthening, cell cycle control and tumor suppression. We have conducted high-resolution 4Pi fluorescence laser-scanning microscopy studies complemented with correlative electron microscopy and investigations of the accessibility of the PML-NB subcompartment. During interphase PML-NBs adopt a spherical organization characterized by the assembly of PML and Sp100 proteins into patches within a 50- to 100-nm-thick shell. This spherical shell of PML and Sp100 imposes little constraint to the exchange of components between the PML-NB interior and the nucleoplasm. Post-translational SUMO modifications, telomere repeats and heterochromatin protein 1 were found to localize in characteristic patterns with respect to PML and Sp100. From our findings, we derived a model that explains how the three-dimensional organization of PML-NBs serves to concentrate different biological activities while allowing for an efficient exchange of components. | lld:pubmed |
| pubmed-article:20130140 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20130140 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20130140 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20130140 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20130140 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20130140 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20130140 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20130140 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20130140 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20130140 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20130140 | pubmed:issn | 1477-9137 | lld:pubmed |
| pubmed-article:20130140 | pubmed:author | pubmed-author:RippeKarstenK | lld:pubmed |
| pubmed-article:20130140 | pubmed:author | pubmed-author:CremerChristo... | lld:pubmed |
| pubmed-article:20130140 | pubmed:author | pubmed-author:HellStefan... | lld:pubmed |
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| pubmed-article:20130140 | pubmed:author | pubmed-author:ChungInnI | lld:pubmed |
| pubmed-article:20130140 | pubmed:author | pubmed-author:JegouThibaudT | lld:pubmed |
| pubmed-article:20130140 | pubmed:author | pubmed-author:LangMarionM | lld:pubmed |
| pubmed-article:20130140 | pubmed:author | pubmed-author:MünchSandraS | lld:pubmed |
| pubmed-article:20130140 | pubmed:author | pubmed-author:UdvarhelyiAni... | lld:pubmed |
| pubmed-article:20130140 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20130140 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:20130140 | pubmed:volume | 123 | lld:pubmed |
| pubmed-article:20130140 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20130140 | pubmed:authorsComplete | Y | lld:pubmed |
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| pubmed-article:20130140 | pubmed:meshHeading | pubmed-meshheading:20130140... | lld:pubmed |
| pubmed-article:20130140 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20130140 | pubmed:articleTitle | Three-dimensional organization of promyelocytic leukemia nuclear bodies. | lld:pubmed |
| pubmed-article:20130140 | pubmed:affiliation | Division of High Resolution Optical Microscopy, Deutsches Krebsforschungszentrum, 69120 Heidelberg, Germany. | lld:pubmed |
| pubmed-article:20130140 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20130140 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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