| pubmed-article:20118769 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20118769 | lifeskim:mentions | umls-concept:C0017636 | lld:lifeskim |
| pubmed-article:20118769 | lifeskim:mentions | umls-concept:C0795878 | lld:lifeskim |
| pubmed-article:20118769 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:20118769 | lifeskim:mentions | umls-concept:C0909824 | lld:lifeskim |
| pubmed-article:20118769 | lifeskim:mentions | umls-concept:C1441616 | lld:lifeskim |
| pubmed-article:20118769 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:20118769 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:20118769 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:20118769 | pubmed:dateCreated | 2010-3-1 | lld:pubmed |
| pubmed-article:20118769 | pubmed:abstractText | Epithelioid and rhabdoid glioblastomas are rare entities that share some overlapping morphologic features, but remain poorly characterized at the immunohistochemical and genetic level. We report 10 examples: 8 epithelioid glioblastomas (E-GBMs) and 2 rhabdoid GBMs (R-GBMs). E-GBMs tended to be superficially located, circumscribed, supratentorial tumors composed of monotonous, discohesive sheets of small rounded cells that mimicked metastatic malignant melanoma. R-GBMs showed tumor with classic rhabdoid features arising as a subpopulation of an otherwise classic GBM, fitting the definition of composite extrarenal rhabdoid tumors. Polyphenotypic immunohistochemical expression and focal loss of INI-1 protein in the rhabdoid areas of R-GBMs distinguished them from E-GBMs. Monosomy 22 was identified in R-GBMs, but not E-GBMs. Immunostaining for claudin-6, a key component of tight junctions that we have earlier shown to be a positive cytoplasmic immunohistochemical marker for atypical teratoid or rhabdoid tumors (AT/RTs), was also conducted. None of the E-GBMs or R-GBMs showed claudin-6 cytoplasmic expression, including the focal areas in the 2 R-GBMs in which there was loss of INI-1 protein nuclear expression. Thus, in the CNS, claudin-6 expression may be a good discriminator of atypical teratoid or rhabdoid tumors from other CNS rhabdoid or epithelioid neoplasms. | lld:pubmed |
| pubmed-article:20118769 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20118769 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20118769 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20118769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20118769 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20118769 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:20118769 | pubmed:issn | 1532-0979 | lld:pubmed |
| pubmed-article:20118769 | pubmed:author | pubmed-author:MooreWayneW | lld:pubmed |
| pubmed-article:20118769 | pubmed:author | pubmed-author:LilleheiKevin... | lld:pubmed |
| pubmed-article:20118769 | pubmed:author | pubmed-author:NewellKathy... | lld:pubmed |
| pubmed-article:20118769 | pubmed:author | pubmed-author:BirksDiane... | lld:pubmed |
| pubmed-article:20118769 | pubmed:author | pubmed-author:Kleinschmidt-... | lld:pubmed |
| pubmed-article:20118769 | pubmed:author | pubmed-author:AlassiriAli... | lld:pubmed |
| pubmed-article:20118769 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20118769 | pubmed:volume | 34 | lld:pubmed |
| pubmed-article:20118769 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20118769 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20118769 | pubmed:pagination | 341-54 | lld:pubmed |
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| pubmed-article:20118769 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20118769 | pubmed:articleTitle | Epithelioid versus rhabdoid glioblastomas are distinguished by monosomy 22 and immunohistochemical expression of INI-1 but not claudin 6. | lld:pubmed |
| pubmed-article:20118769 | pubmed:affiliation | Department of Pathology, Anschutz Medical Campus, University of Colorado at Denver, Denver, Colorado 80045, USA. bk.demasters@ucdenver.edu | lld:pubmed |
| pubmed-article:20118769 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20118769 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:20118769 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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