| pubmed-article:20117098 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20117098 | lifeskim:mentions | umls-concept:C0542341 | lld:lifeskim |
| pubmed-article:20117098 | lifeskim:mentions | umls-concept:C0205419 | lld:lifeskim |
| pubmed-article:20117098 | lifeskim:mentions | umls-concept:C0678594 | lld:lifeskim |
| pubmed-article:20117098 | lifeskim:mentions | umls-concept:C0205214 | lld:lifeskim |
| pubmed-article:20117098 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:20117098 | pubmed:dateCreated | 2010-3-1 | lld:pubmed |
| pubmed-article:20117098 | pubmed:abstractText | Human apolipoprotein A-IV (apoA-IV) is involved in chylomicron assembly and secretion, and in reverse cholesterol transport. Several apoA-IV isoforms exist, the most common in Caucasian populations being apoA-IV-1a (T347S) and apoA-IV-2 (Q360H). The objective of the present study was to investigate the impact of these common aminoacid substitutions on the ability of apoA-IV to bind lipids, to promote cell cholesterol efflux via ABCA1, and to maintain endothelial homeostasis. Recombinant forms of wild-type apoA-IV, apoA-IV Q360H, and apoA-IV T347S were produced in Escherichia coli. ApoA-IV Q360H and apoA-IV T347S showed a slightly higher alpha-helical content compared to wild-type apoA-IV, and associated with phospholipids faster than wild-type apoA-IV. The capacity to promote ABCA1-mediated cholesterol efflux was significantly greater for the apoA-IV T347S than the other apoA-IV isoforms. No differences were observed in the ability of apoA-IV isoforms to inhibit the production of VCAM-1 and IL-6 in TNFalpha-stimulated endothelial cells. In conclusion, the apoA-IV T347S common variant has increased lipid binding properties and cholesterol efflux capacity, while the apoA-IV Q360H variant has only slightly increased lipid binding properties. The two common aminoacid substitutions have no effect on the ability of apoA-IV to maintain endothelial homeostasis. | lld:pubmed |
| pubmed-article:20117098 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20117098 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20117098 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20117098 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20117098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20117098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20117098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20117098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20117098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20117098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20117098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20117098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20117098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20117098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20117098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20117098 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20117098 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20117098 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:20117098 | pubmed:issn | 1090-2104 | lld:pubmed |
| pubmed-article:20117098 | pubmed:author | pubmed-author:GomaraschiMon... | lld:pubmed |
| pubmed-article:20117098 | pubmed:author | pubmed-author:CalabresiLaur... | lld:pubmed |
| pubmed-article:20117098 | pubmed:author | pubmed-author:FranceschiniG... | lld:pubmed |
| pubmed-article:20117098 | pubmed:author | pubmed-author:IamettiStefan... | lld:pubmed |
| pubmed-article:20117098 | pubmed:author | pubmed-author:BonomiFrances... | lld:pubmed |
| pubmed-article:20117098 | pubmed:author | pubmed-author:TalmudPhilipp... | lld:pubmed |
| pubmed-article:20117098 | pubmed:author | pubmed-author:BerniniFranco... | lld:pubmed |
| pubmed-article:20117098 | pubmed:author | pubmed-author:PozziSilviaS | lld:pubmed |
| pubmed-article:20117098 | pubmed:author | pubmed-author:BarbiroliAlbe... | lld:pubmed |
| pubmed-article:20117098 | pubmed:author | pubmed-author:FavariEldaE | lld:pubmed |
| pubmed-article:20117098 | pubmed:author | pubmed-author:PuttWendy EWE | lld:pubmed |
| pubmed-article:20117098 | pubmed:copyrightInfo | Copyright 2010 Elsevier Inc. All rights reserved. | lld:pubmed |
| pubmed-article:20117098 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20117098 | pubmed:day | 26 | lld:pubmed |
| pubmed-article:20117098 | pubmed:volume | 393 | lld:pubmed |
| pubmed-article:20117098 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20117098 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20117098 | pubmed:pagination | 126-30 | lld:pubmed |
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| pubmed-article:20117098 | pubmed:meshHeading | pubmed-meshheading:20117098... | lld:pubmed |
| pubmed-article:20117098 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20117098 | pubmed:articleTitle | Structure and function of the apoA-IV T347S and Q360H common variants. | lld:pubmed |
| pubmed-article:20117098 | pubmed:affiliation | Center E. Grossi Paoletti, Department of Pharmacological Sciences, Università degli Studi di Milano, 20133 Milano, Italy. | lld:pubmed |
| pubmed-article:20117098 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20117098 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:337 | entrezgene:pubmed | pubmed-article:20117098 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:20117098 | lld:entrezgene |
