| pubmed-article:20116863 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20116863 | lifeskim:mentions | umls-concept:C0026769 | lld:lifeskim |
| pubmed-article:20116863 | lifeskim:mentions | umls-concept:C1537399 | lld:lifeskim |
| pubmed-article:20116863 | lifeskim:mentions | umls-concept:C0004083 | lld:lifeskim |
| pubmed-article:20116863 | lifeskim:mentions | umls-concept:C0522498 | lld:lifeskim |
| pubmed-article:20116863 | lifeskim:mentions | umls-concept:C0332125 | lld:lifeskim |
| pubmed-article:20116863 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:20116863 | pubmed:dateCreated | 2010-4-12 | lld:pubmed |
| pubmed-article:20116863 | pubmed:abstractText | Studies suggest that different autoimmune diseases share a common genetic background, in particular, an overlap between Multiple Sclerosis (MS) and type 1 diabetes (T1D) susceptibility loci has been established. A recent study found that four rare SNPs in the IFIH1 (interferon induced with helicase C domain 1) were significantly associated with T1D. To establish if these SNPs were also involved in MS susceptibility, we chose to examine the non-synonymous SNP rs35667974/Ile923Val which displayed the strongest effect in T1D and was also shown to lead to a loss of IFIH1 function in an in vitro study. We have performed the first association study to test if this rare variant is involved in MS susceptibility in a very large sample consisting of 3037 MS patients and 10,657 healthy controls recruited from Italy and the UK. This study has 99% power to demonstrate an association at the 5% level with this rare variant. Our analysis shows that the nsSNP rs35667974/Ile923Val does not have a role in susceptibility to MS. | lld:pubmed |
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| pubmed-article:20116863 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20116863 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20116863 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20116863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20116863 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20116863 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20116863 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:20116863 | pubmed:issn | 1872-8421 | lld:pubmed |
| pubmed-article:20116863 | pubmed:author | pubmed-author:D'AlfonsoSand... | lld:pubmed |
| pubmed-article:20116863 | pubmed:author | pubmed-author:BanMariaM | lld:pubmed |
| pubmed-article:20116863 | pubmed:author | pubmed-author:SawcerStephen... | lld:pubmed |
| pubmed-article:20116863 | pubmed:author | pubmed-author:LeoneMaurizio... | lld:pubmed |
| pubmed-article:20116863 | pubmed:author | pubmed-author:BergamaschiLa... | lld:pubmed |
| pubmed-article:20116863 | pubmed:copyrightInfo | Copyright 2010 Elsevier B.V. All rights reserved. | lld:pubmed |
| pubmed-article:20116863 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20116863 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:20116863 | pubmed:volume | 221 | lld:pubmed |
| pubmed-article:20116863 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20116863 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20116863 | pubmed:pagination | 112-4 | lld:pubmed |
| pubmed-article:20116863 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:20116863 | pubmed:meshHeading | pubmed-meshheading:20116863... | lld:pubmed |
| pubmed-article:20116863 | pubmed:meshHeading | pubmed-meshheading:20116863... | lld:pubmed |
| pubmed-article:20116863 | pubmed:meshHeading | pubmed-meshheading:20116863... | lld:pubmed |
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| pubmed-article:20116863 | pubmed:meshHeading | pubmed-meshheading:20116863... | lld:pubmed |
| pubmed-article:20116863 | pubmed:meshHeading | pubmed-meshheading:20116863... | lld:pubmed |
| pubmed-article:20116863 | pubmed:meshHeading | pubmed-meshheading:20116863... | lld:pubmed |
| pubmed-article:20116863 | pubmed:meshHeading | pubmed-meshheading:20116863... | lld:pubmed |
| pubmed-article:20116863 | pubmed:meshHeading | pubmed-meshheading:20116863... | lld:pubmed |
| pubmed-article:20116863 | pubmed:meshHeading | pubmed-meshheading:20116863... | lld:pubmed |
| pubmed-article:20116863 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20116863 | pubmed:articleTitle | No evidence of association of the rare nsSNP rs35667974 in IFIH1 with multiple sclerosis. | lld:pubmed |
| pubmed-article:20116863 | pubmed:affiliation | Department of Medical Sciences, Interdisciplinary Research Center of Autoimmune Diseases (IRCAD), University of Eastern Piedmont, Novara, Italy. laura.bergamaschi@med.unipmn.it | lld:pubmed |
| pubmed-article:20116863 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20116863 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:20116863 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:64135 | entrezgene:pubmed | pubmed-article:20116863 | lld:entrezgene |
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