| pubmed-article:20110268 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20110268 | lifeskim:mentions | umls-concept:C0032961 | lld:lifeskim |
| pubmed-article:20110268 | lifeskim:mentions | umls-concept:C0028754 | lld:lifeskim |
| pubmed-article:20110268 | lifeskim:mentions | umls-concept:C0036945 | lld:lifeskim |
| pubmed-article:20110268 | lifeskim:mentions | umls-concept:C1858460 | lld:lifeskim |
| pubmed-article:20110268 | lifeskim:mentions | umls-concept:C0015935 | lld:lifeskim |
| pubmed-article:20110268 | lifeskim:mentions | umls-concept:C0232164 | lld:lifeskim |
| pubmed-article:20110268 | lifeskim:mentions | umls-concept:C1257763 | lld:lifeskim |
| pubmed-article:20110268 | lifeskim:mentions | umls-concept:C2611812 | lld:lifeskim |
| pubmed-article:20110268 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20110268 | pubmed:dateCreated | 2010-6-2 | lld:pubmed |
| pubmed-article:20110268 | pubmed:abstractText | Maternal obesity in pregnancy predisposes offspring to insulin resistance and associated cardiovascular disease. Here, we used a well-established sheep model to investigate the effects of maternal obesity on cardiac functions. Multiparous ewes were assigned to a control (CON) diet [100% of National Research Council (NRC) recommendations] or an obesogenic (OB) diet (150% of NRC recommendations) from 60 d before conception to necropsy on d 135 of pregnancy. Fetal blood glucose and insulin were increased (P<0.01, n=8) in OB (35.09+/-2.03 mg/dl and 3.40+/-1.43 microU/ml, respectively) vs. CON ewes (23.80+/-1.38 mg/dl and 0.769+/-0.256 microU/ml). Phosphorylation of AMP-activated protein kinase (AMPK), a cardioprotective signaling pathway, was reduced (P<0.05), while the stress signaling pathway, p38 MAPK, was up-regulated (P<0.05) in OB maternal and fetal hearts. Phosphorylation of c-Jun N-terminal kinase (JNK) and insulin receptor substrate-1 (IRS-1) at Ser-307 were increased (P<0.05) in OB fetal heart associated with lower downstream PI3K-Akt activity (P<0.05), indicating impaired cardiac insulin signaling. Although OB fetal hearts exhibited a normal contractile function vs. CON fetal hearts during basal perfusion, they developed an impaired heart-rate-left-ventricular-developed pressure product in response to high workload stress. Taken together, fetuses of OB mothers demonstrate alterations in cardiac PI3K-Akt, AMPK, and JNK-IRS-1 signaling pathways that would predispose them to insulin resistance and cardiac dysfunction. | lld:pubmed |
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| pubmed-article:20110268 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20110268 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20110268 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20110268 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:20110268 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20110268 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20110268 | pubmed:issn | 1530-6860 | lld:pubmed |
| pubmed-article:20110268 | pubmed:author | pubmed-author:OngY WYW | lld:pubmed |
| pubmed-article:20110268 | pubmed:author | pubmed-author:HeinHHJr | lld:pubmed |
| pubmed-article:20110268 | pubmed:author | pubmed-author:ZangMengweiM | lld:pubmed |
| pubmed-article:20110268 | pubmed:author | pubmed-author:LuJuJ | lld:pubmed |
| pubmed-article:20110268 | pubmed:author | pubmed-author:NathanielszPe... | lld:pubmed |
| pubmed-article:20110268 | pubmed:author | pubmed-author:TongChaoC | lld:pubmed |
| pubmed-article:20110268 | pubmed:author | pubmed-author:FordStephen... | lld:pubmed |
| pubmed-article:20110268 | pubmed:author | pubmed-author:NijlandMark... | lld:pubmed |
| pubmed-article:20110268 | pubmed:author | pubmed-author:WangJingyingJ | lld:pubmed |
| pubmed-article:20110268 | pubmed:author | pubmed-author:ZhangHanyingH | lld:pubmed |
| pubmed-article:20110268 | pubmed:author | pubmed-author:LawlisGavin... | lld:pubmed |
| pubmed-article:20110268 | pubmed:author | pubmed-author:LiYuandaY | lld:pubmed |
| pubmed-article:20110268 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20110268 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:20110268 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20110268 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20110268 | pubmed:pagination | 2066-76 | lld:pubmed |
| pubmed-article:20110268 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:20110268 | pubmed:meshHeading | pubmed-meshheading:20110268... | lld:pubmed |
| pubmed-article:20110268 | pubmed:meshHeading | pubmed-meshheading:20110268... | lld:pubmed |
| pubmed-article:20110268 | pubmed:meshHeading | pubmed-meshheading:20110268... | lld:pubmed |
