| pubmed-article:20103721 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20103721 | lifeskim:mentions | umls-concept:C1961099 | lld:lifeskim |
| pubmed-article:20103721 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:20103721 | lifeskim:mentions | umls-concept:C0666728 | lld:lifeskim |
| pubmed-article:20103721 | lifeskim:mentions | umls-concept:C0376515 | lld:lifeskim |
| pubmed-article:20103721 | lifeskim:mentions | umls-concept:C0242210 | lld:lifeskim |
| pubmed-article:20103721 | lifeskim:mentions | umls-concept:C1148853 | lld:lifeskim |
| pubmed-article:20103721 | lifeskim:mentions | umls-concept:C1314939 | lld:lifeskim |
| pubmed-article:20103721 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20103721 | pubmed:dateCreated | 2010-6-2 | lld:pubmed |
| pubmed-article:20103721 | pubmed:abstractText | The human antiapoptotic bcl-2 gene has been discovered in t(14;18) B-cell leukemias/lymphomas because of its overexpression caused at a transcriptional control level by the bcl-2/IgH fusion gene. We were the first to disclose the post-transcriptional control of bcl-2 expression mediated by interactions of an adenine + uracil (AU)-rich element (ARE) in the 3'-UTR of bcl-2 mRNA with AU-binding proteins (AUBPs). Here, we identify and characterize zeta-crystallin as a new bcl-2 AUBP, whose silencing or overexpression has impact on bcl-2 mRNA stability. An increased Bcl-2 level observed in normal phytohemagglutinin (PHA)-activated T lymphocytes, acute lymphatic leukemia (ALL) T-cell lines, and T cells of patients with leukemia in comparison with normal non-PHA-activated T lymphocytes was concomitant with an increase in zeta-crystallin level. The specific association of zeta-crystallin with the bcl-2 ARE was significantly enhanced in T cells of patients with ALL, which accounts for the higher stability of bcl-2 mRNA and suggests a possible contribution of zeta-crystallin to bcl-2 overexpression occurring in this leukemia. | lld:pubmed |
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| pubmed-article:20103721 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20103721 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20103721 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20103721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20103721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20103721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20103721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20103721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20103721 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20103721 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20103721 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20103721 | pubmed:issn | 1530-6860 | lld:pubmed |
| pubmed-article:20103721 | pubmed:author | pubmed-author:BXX | lld:pubmed |
| pubmed-article:20103721 | pubmed:author | pubmed-author:CapaccioliSer... | lld:pubmed |
| pubmed-article:20103721 | pubmed:author | pubmed-author:PapucciLauraL | lld:pubmed |
| pubmed-article:20103721 | pubmed:author | pubmed-author:SchiavoneNico... | lld:pubmed |
| pubmed-article:20103721 | pubmed:author | pubmed-author:DonniniMartin... | lld:pubmed |
| pubmed-article:20103721 | pubmed:author | pubmed-author:LapucciAndrea... | lld:pubmed |
| pubmed-article:20103721 | pubmed:author | pubmed-author:WitortEwaE | lld:pubmed |
| pubmed-article:20103721 | pubmed:author | pubmed-author:NicolinAngelo... | lld:pubmed |
| pubmed-article:20103721 | pubmed:author | pubmed-author:BrewerGaryG | lld:pubmed |
| pubmed-article:20103721 | pubmed:author | pubmed-author:MorelloDomini... | lld:pubmed |
| pubmed-article:20103721 | pubmed:author | pubmed-author:BertoliniFran... | lld:pubmed |
| pubmed-article:20103721 | pubmed:author | pubmed-author:BevilacquaAnn... | lld:pubmed |
| pubmed-article:20103721 | pubmed:author | pubmed-author:LulliMatteoM | lld:pubmed |
| pubmed-article:20103721 | pubmed:author | pubmed-author:Di... | lld:pubmed |
| pubmed-article:20103721 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20103721 | pubmed:volume | 24 | lld:pubmed |
| pubmed-article:20103721 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20103721 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20103721 | pubmed:pagination | 1852-65 | lld:pubmed |
| pubmed-article:20103721 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
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| pubmed-article:20103721 | pubmed:meshHeading | pubmed-meshheading:20103721... | lld:pubmed |
| pubmed-article:20103721 | pubmed:meshHeading | pubmed-meshheading:20103721... | lld:pubmed |
| pubmed-article:20103721 | pubmed:meshHeading | pubmed-meshheading:20103721... | lld:pubmed |
| pubmed-article:20103721 | pubmed:meshHeading | pubmed-meshheading:20103721... | lld:pubmed |
| pubmed-article:20103721 | pubmed:meshHeading | pubmed-meshheading:20103721... | lld:pubmed |
